ATG4B (autophagy related 4B cysteine peptidase)

2003-10-01  

Identity

HGNC
LOCATION
2q37.3
LOCUSID
ALIAS
APG4B,AUTL1
FUSION GENES

Other Information

Locus ID:

NCBI: 23192
MIM: 611338
HGNC: 20790
Ensembl: ENSG00000168397

Variants:

dbSNP: 23192
ClinVar: 23192
TCGA: ENSG00000168397
COSMIC: ATG4B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168397ENST00000344376H0Y2Y0
ENSG00000168397ENST00000400771C9JIK8
ENSG00000168397ENST00000400772F2Z2K8
ENSG00000168397ENST00000402096Q9Y4P1
ENSG00000168397ENST00000404914Q9Y4P1
ENSG00000168397ENST00000405546Q9Y4P1
ENSG00000168397ENST00000415107F2Z2K8
ENSG00000168397ENST00000419606C9J1C1
ENSG00000168397ENST00000625810F2Z2K8

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
Autophagy - otherKEGGko04136
Autophagy - otherKEGGhsa04136

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
193221942009The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy.149
151870942004HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates.140
211778652011Kinetics comparisons of mammalian Atg4 homologues indicate selective preferences toward diverse Atg8 substrates.74
161836332005Structural basis for the specificity and catalysis of human Atg4B responsible for mammalian autophagy.53
247554092014The core autophagy protein ATG4B is a potential biomarker and therapeutic target in CML stem/progenitor cells.52
292325562017MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma.43
235080062013Autophagy facilitates organelle clearance during differentiation of human erythroblasts: evidence for a role for ATG4 paralogs during autophagosome maturation.33
163258512006The crystal structure of human Atg4b, a processing and de-conjugating enzyme for autophagosome-forming modifiers.31
282873292017ATG4B contains a C-terminal LIR motif important for binding and efficient cleavage of mammalian orthologs of yeast Atg8.28
288217082017A reversible phospho-switch mediated by ULK1 regulates the activity of autophagy protease ATG4B.28

Citation

Dessen P

ATG4B (autophagy related 4B cysteine peptidase)

Atlas Genet Cytogenet Oncol Haematol. 2003-10-01

Online version: http://atlasgeneticsoncology.org/gene/672/atg4b-(autophagy-related-4b-cysteine-peptidase)