ATG4C (autophagy related 4C cysteine peptidase)

2003-10-01  

Identity

HGNC
LOCATION
1p31.3
LOCUSID
ALIAS
APG4-C,APG4C,AUTL1,AUTL3
FUSION GENES

Other Information

Locus ID:

NCBI: 84938
MIM: 611339
HGNC: 16040
Ensembl: ENSG00000125703

Variants:

dbSNP: 84938
ClinVar: 84938
TCGA: ENSG00000125703
COSMIC: ATG4C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125703ENST00000317868Q96DT6
ENSG00000125703ENST00000317868A0A384MTY5
ENSG00000125703ENST00000371118A6NGQ4
ENSG00000125703ENST00000371120Q96DT6
ENSG00000125703ENST00000371120A0A384MTY5
ENSG00000125703ENST00000414558H7BZW5
ENSG00000125703ENST00000443289C9JC51

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
Autophagy - otherKEGGko04136
Autophagy - otherKEGGhsa04136

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
222487182012miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1.92
284235112017ATM kinase sustains breast cancer stem-like cells by promoting ATG4C expression and autophagy.10
306614292019Redundancy of human ATG4 protease isoforms in autophagy and LC3/GABARAP processing revealed in cells.8
312919882019Knockdown ATG4C inhibits gliomas progression and promotes temozolomide chemosensitivity by suppressing autophagic flux.3
277425322017Genetic association, mRNA and protein expression analysis identify ATG4C as a susceptibility gene for Kashin-Beck disease.2

Citation

Dessen P

ATG4C (autophagy related 4C cysteine peptidase)

Atlas Genet Cytogenet Oncol Haematol. 2003-10-01

Online version: http://atlasgeneticsoncology.org/gene/673/atg4c-(autophagy-related-4c-cysteine-peptidase)