APOBEC1 (apolipoprotein B mRNA editing enzyme catalytic subunit 1)

2003-05-01  

Identity

HGNC
APOBEC1
LOCATION
12p13.31
LOCUSID
339
ALIAS
APOBEC-1,BEDP,CDAR1,HEPR

Other Information

Locus ID:

NCBI: 339
MIM: 600130
HGNC: 604
Ensembl: ENSG00000111701

Variants:

dbSNP: 339
ClinVar: 339
TCGA: ENSG00000111701
COSMIC: APOBEC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111701ENST00000229304P41238
ENSG00000111701ENST00000467171A0A0B4J232

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
mRNA EditingREACTOMER-HSA-75072
mRNA Editing: C to U ConversionREACTOMER-HSA-72200
Formation of the EditosomeREACTOMER-HSA-75094

References

Pubmed IDYearTitleCitations
367029982023APOBEC mutagenesis is a common process in normal human small intestine.9
387081902023Identification of RBM46 as a novel APOBEC1 cofactor for C-to-U RNA-editing activity.0
367029982023APOBEC mutagenesis is a common process in normal human small intestine.9
387081902023Identification of RBM46 as a novel APOBEC1 cofactor for C-to-U RNA-editing activity.0
361006312022The roles of APOBEC-mediated RNA editing in SARS-CoV-2 mutations, replication and fitness.40
361006312022The roles of APOBEC-mediated RNA editing in SARS-CoV-2 mutations, replication and fitness.40
333309052021APOBEC1 cytosine deaminase activity on single-stranded DNA is suppressed by replication protein A.13
336022352021Harnessing A3G for efficient and selective C-to-T conversion at C-rich sequences.0
333309052021APOBEC1 cytosine deaminase activity on single-stranded DNA is suppressed by replication protein A.13
336022352021Harnessing A3G for efficient and selective C-to-T conversion at C-rich sequences.0
293465132018Pancancer analysis identifies prognostic high-APOBEC1 expression level implicated in cancer in-frame insertions and deletions.15
293465132018Pancancer analysis identifies prognostic high-APOBEC1 expression level implicated in cancer in-frame insertions and deletions.15
286398932017Apobec-1 complementation factor regulates cell migration and apoptosis through Dickkopf1 by acting on its 3' untranslated region in MCF7 cells.3
286398932017Apobec-1 complementation factor regulates cell migration and apoptosis through Dickkopf1 by acting on its 3' untranslated region in MCF7 cells.3
258393282015Genomic analyses reveal mutational signatures and frequently altered genes in esophageal squamous cell carcinoma.184

Citation

Dessen P

APOBEC1 (apolipoprotein B mRNA editing enzyme catalytic subunit 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/676/case-report-explorer/js/lib/zoomerang.js