ARHGAP24 (Rho GTPase activating protein 24)

2003-05-01  

Identity

HGNC
ARHGAP24
LOCATION
4q21.23
LOCUSID
83478
ALIAS
FILGAP,RC-GAP72,RCGAP72,p73,p73RhoGAP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 83478
MIM: 610586
HGNC: 25361
Ensembl: ENSG00000138639

Variants:

dbSNP: 83478
ClinVar: 83478
TCGA: ENSG00000138639
COSMIC: ARHGAP24

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138639ENST00000264343Q8N264
ENSG00000138639ENST00000395183Q8N264
ENSG00000138639ENST00000395184Q8N264
ENSG00000138639ENST00000503995Q8N264
ENSG00000138639ENST00000509300D6RBC2
ENSG00000138639ENST00000512201D6RHH1
ENSG00000138639ENST00000514229D6RCP5

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
387425662024Exosome-transmitted circular RNA circ-LMO7 facilitates the progression of osteosarcoma by regulating miR-21-5p/ARHGAP24 axis.0
387425662024Exosome-transmitted circular RNA circ-LMO7 facilitates the progression of osteosarcoma by regulating miR-21-5p/ARHGAP24 axis.0
380659682023FilGAP regulates tumor growth in Glioma through the regulation of mTORC1 and mTORC2.1
380659682023FilGAP regulates tumor growth in Glioma through the regulation of mTORC1 and mTORC2.1
361686272022ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.7
361686272022ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.7
337107062021FilGAP, a GAP protein for Rac, regulates front-rear polarity and tumor cell migration through the ECM.5
337107062021FilGAP, a GAP protein for Rac, regulates front-rear polarity and tumor cell migration through the ECM.5
314303742020ARHGAP24 inhibits cell proliferation and cell cycle progression and induces apoptosis of lung cancer via a STAT6-WWP2-p27 axis.19
317858162020AGAP1 regulates subcellular localization of FilGAP and control cancer cell invasion.7
319353902020HOTAIRM1 suppresses cell proliferation and invasion in ovarian cancer through facilitating ARHGAP24 expression by sponging miR-106a-5p.23
314303742020ARHGAP24 inhibits cell proliferation and cell cycle progression and induces apoptosis of lung cancer via a STAT6-WWP2-p27 axis.19
317858162020AGAP1 regulates subcellular localization of FilGAP and control cancer cell invasion.7
319353902020HOTAIRM1 suppresses cell proliferation and invasion in ovarian cancer through facilitating ARHGAP24 expression by sponging miR-106a-5p.23
305991322019Rho GTPase Activating Protein 24 (ARHGAP24) Silencing Promotes Lung Cancer Cell Migration and Invasion by Activating β-Catenin Signaling.9

Citation

Dessen P

ARHGAP24 (Rho GTPase activating protein 24)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/695/favicon/cancer-prone-explorer/favicon/favicon-32x32.png