ARHGAP4 (Rho GTPase activating protein 4)

2003-05-01  

Identity

HGNC
ARHGAP4
LOCATION
Xq28
LOCUSID
393
ALIAS
C1,RGC1,RhoGAP4,SrGAP4,p115
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 393
MIM: 300023
HGNC: 674
Ensembl: ENSG00000089820

Variants:

dbSNP: 393
ClinVar: 393
TCGA: ENSG00000089820
COSMIC: ARHGAP4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000089820ENST00000350060P98171
ENSG00000089820ENST00000370016E7EQN5
ENSG00000089820ENST00000370028P98171
ENSG00000089820ENST00000393721E9PCM6
ENSG00000089820ENST00000404127F8WAR0
ENSG00000089820ENST00000418750H7C3G3
ENSG00000089820ENST00000420383A0A0B4J1X7
ENSG00000089820ENST00000422091C9JLA8
ENSG00000089820ENST00000422918H7C120
ENSG00000089820ENST00000442172H7C2Z8
ENSG00000089820ENST00000442262C9J5M2
ENSG00000089820ENST00000454164H7C3K8
ENSG00000089820ENST00000461052S4R314
ENSG00000089820ENST00000488269S4R352

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
389050342024Rho GTPase-activating protein 4 is upregulated in Kidney Renal Clear Cell Carcinoma and associated with poor prognosis and immune infiltration.0
389050342024Rho GTPase-activating protein 4 is upregulated in Kidney Renal Clear Cell Carcinoma and associated with poor prognosis and immune infiltration.0
374433032023ARHGAP4 promotes leukemogenesis in acute myeloid leukemia by inhibiting DRAM1 signaling.0
374433032023ARHGAP4 promotes leukemogenesis in acute myeloid leukemia by inhibiting DRAM1 signaling.0
362888772022Candidate Oncogenes, ARHGAP4, NOS3, and OR51B5, for the Development of Scirrhous-type Gastric Cancer.2
362888772022Candidate Oncogenes, ARHGAP4, NOS3, and OR51B5, for the Development of Scirrhous-type Gastric Cancer.2
345248732021ARHGAP4-SEPT2-SEPT9 complex enables both up- and down-modulation of integrin-mediated focal adhesions, cell migration, and invasion.3
345248732021ARHGAP4-SEPT2-SEPT9 complex enables both up- and down-modulation of integrin-mediated focal adhesions, cell migration, and invasion.3
323782602020Comprehensive analysis on the whole Rho-GAP family reveals that ARHGAP4 suppresses EMT in epithelial cells under negative regulation by Septin9.14
323782602020Comprehensive analysis on the whole Rho-GAP family reveals that ARHGAP4 suppresses EMT in epithelial cells under negative regulation by Septin9.14
309585312019ARHGAP4 regulates the cell migration and invasion of pancreatic cancer by the HDAC2/β-catenin signaling pathway.17
309585312019ARHGAP4 regulates the cell migration and invasion of pancreatic cancer by the HDAC2/β-catenin signaling pathway.17
267072112016ARHGAP4 mutated in a Chinese intellectually challenged family.4
267072112016ARHGAP4 mutated in a Chinese intellectually challenged family.4
240438782014Common variants on Xq28 conferring risk of schizophrenia in Han Chinese.20

Citation

Dessen P

ARHGAP4 (Rho GTPase activating protein 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/696/teaching-explorer/favicon/css/template-nav.css