MOGS (mannosyl-oligosaccharide glucosidase)

2014-11-01  

Identity

HGNC
MOGS
LOCATION
2p13.1
LOCUSID
7841
ALIAS
CDG2B,CWH41,DER7,GCS1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7841
MIM: 601336
HGNC: 24862
Ensembl: ENSG00000115275

Variants:

dbSNP: 7841
ClinVar: 7841
TCGA: ENSG00000115275
COSMIC: MOGS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115275ENST00000409065B8ZZE2
ENSG00000115275ENST00000414701C9JDQ1
ENSG00000115275ENST00000448666Q13724
ENSG00000115275ENST00000448666A0A384MDR6
ENSG00000115275ENST00000452063Q13724
ENSG00000115275ENST00000462443A0A3B3IRW2
ENSG00000115275ENST00000647723A0A3B3ITU6
ENSG00000115275ENST00000647753B4E3B8
ENSG00000115275ENST00000647771A0A3B3IRI1
ENSG00000115275ENST00000647915A0A3B3IU81
ENSG00000115275ENST00000648810A0A3B3IRW2
ENSG00000115275ENST00000649075A0A3B3ITC1
ENSG00000115275ENST00000649601A0A3B3IRI7
ENSG00000115275ENST00000649854A0A3B3IRK6
ENSG00000115275ENST00000650523A0A3B3IS52

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
N-Glycan biosynthesisKEGGko00510
N-Glycan biosynthesisKEGGhsa00510
Metabolic pathwaysKEGGhsa01100
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
N-glycan precursor trimmingKEGGhsa_M00073
N-glycan precursor trimmingKEGGM00073
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
N-glycan trimming in the ER and Calnexin/Calreticulin cycleREACTOMER-HSA-532668

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
332619252021Congenital disorders of glycosylation type IIb with MOGS mutations cause early infantile epileptic encephalopathy, dysmorphic features, and hepatic dysfunction.3
332619252021Congenital disorders of glycosylation type IIb with MOGS mutations cause early infantile epileptic encephalopathy, dysmorphic features, and hepatic dysfunction.3
305878462019Compound heterozygous variants in MOGS inducing congenital disorders of glycosylation (CDG) IIb.5
305878462019Compound heterozygous variants in MOGS inducing congenital disorders of glycosylation (CDG) IIb.5
247166612014Glycosylation, hypogammaglobulinemia, and resistance to viral infections.59
247166612014Glycosylation, hypogammaglobulinemia, and resistance to viral infections.59
126264092003(Arg)3 within the N-terminal domain of glucosidase I contains ER targeting information but is not required absolutely for ER localization.8
126264092003(Arg)3 within the N-terminal domain of glucosidase I contains ER targeting information but is not required absolutely for ER localization.8
119428562002Perturbation of free oligosaccharide trafficking in endoplasmic reticulum glucosidase I-deficient and castanospermine-treated cells.10
124902812002Cloning MafF by recognition site screening with the NFE2 tandem repeat of HS2: analysis of its role in globin and GCSl genes regulation.8
119428562002Perturbation of free oligosaccharide trafficking in endoplasmic reticulum glucosidase I-deficient and castanospermine-treated cells.10
124902812002Cloning MafF by recognition site screening with the NFE2 tandem repeat of HS2: analysis of its role in globin and GCSl genes regulation.8

Citation

Dessen P

MOGS (mannosyl-oligosaccharide glucosidase)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70367/js/css/template-card.css