ARL3 (ADP ribosylation factor like GTPase 3)

2003-11-01  

Identity

HGNC
ARL3
LOCATION
10q24.32
LOCUSID
403
ALIAS
ARFL3,JBTS35,RP83
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 403
MIM: 604695
HGNC: 694
Ensembl: ENSG00000138175

Variants:

dbSNP: 403
ClinVar: 403
TCGA: ENSG00000138175
COSMIC: ARL3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138175ENST00000260746P36405

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Cargo trafficking to the periciliary membraneREACTOMER-HSA-5620920
Trafficking of myristoylated proteins to the ciliumREACTOMER-HSA-5624138

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384572492024Mechanisms underlying morphological and functional changes of cilia in fibroblasts derived from patients bearing ARL3(T31A) and ARL3(T31A/C118F) mutations.0
384572492024Mechanisms underlying morphological and functional changes of cilia in fibroblasts derived from patients bearing ARL3(T31A) and ARL3(T31A/C118F) mutations.0
374400462023Human Mutations in Arl3, a Small GTPase Involved in Lipidated Cargo Delivery to the Cilia, Cause Retinal Dystrophy.0
374400462023Human Mutations in Arl3, a Small GTPase Involved in Lipidated Cargo Delivery to the Cilia, Cause Retinal Dystrophy.0
334385812021ARL3 activation requires the co-GEF BART and effector-mediated turnover.10
342089322021Mechanism of Guanosine Triphosphate Hydrolysis by the Visual Proteins Arl3-RP2: Free Energy Reaction Profiles Computed with Ab Initio Type QM/MM Potentials.3
334385812021ARL3 activation requires the co-GEF BART and effector-mediated turnover.10
342089322021Mechanism of Guanosine Triphosphate Hydrolysis by the Visual Proteins Arl3-RP2: Free Energy Reaction Profiles Computed with Ab Initio Type QM/MM Potentials.3
332979412020Expression patterns of ciliopathy genes ARL3 and CEP120 reveal roles in multisystem development.4
332979412020Expression patterns of ciliopathy genes ARL3 and CEP120 reveal roles in multisystem development.4
309327212019Dominant ARL3-related retinitis pigmentosa.11
312348702019ARL3 is downregulated and acts as a prognostic biomarker in glioma.17
317439392019Homozygous Variant in ARL3 Causes Autosomal Recessive Cone Rod Dystrophy.8
309327212019Dominant ARL3-related retinitis pigmentosa.11
312348702019ARL3 is downregulated and acts as a prognostic biomarker in glioma.17

Citation

Dessen P

ARL3 (ADP ribosylation factor like GTPase 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/706/tumors-explorer/js/_common.js