NAGK (N-acetylglucosamine kinase)

2014-11-01  

Identity

HGNC
NAGK
LOCATION
2p13.3
LOCUSID
55577
ALIAS
GNK,HSA242910
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55577
MIM: 606828
HGNC: 17174
Ensembl: ENSG00000124357

Variants:

dbSNP: 55577
ClinVar: 55577
TCGA: ENSG00000124357
COSMIC: NAGK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124357ENST00000244204Q9UJ70
ENSG00000124357ENST00000244204A0A384N6G7
ENSG00000124357ENST00000418807C9JEV6
ENSG00000124357ENST00000443872H7C286
ENSG00000124357ENST00000443938H7C3G9
ENSG00000124357ENST00000450272H7C1L7
ENSG00000124357ENST00000455197C9JMR7
ENSG00000124357ENST00000455662Q9UJ70
ENSG00000124357ENST00000524537H0YF44
ENSG00000124357ENST00000524736H0YEB7
ENSG00000124357ENST00000529236H0YC94
ENSG00000124357ENST00000531934E9PPU6
ENSG00000124357ENST00000533981H0YE82
ENSG00000124357ENST00000613852Q9UJ70

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Amino sugar and nucleotide sugar metabolismKEGGko00520
Amino sugar and nucleotide sugar metabolismKEGGhsa00520
Metabolic pathwaysKEGGhsa01100
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinREACTOMER-HSA-446193
Synthesis of substrates in N-glycan biosythesisREACTOMER-HSA-446219
Synthesis of UDP-N-acetyl-glucosamineREACTOMER-HSA-446210

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
386126132024The Immunometabolic Gene N-Acetylglucosamine Kinase Is Uniquely Involved in the Heritability of Multiple Sclerosis Severity.0
386126132024The Immunometabolic Gene N-Acetylglucosamine Kinase Is Uniquely Involved in the Heritability of Multiple Sclerosis Severity.0
375114332023N-Acetylglucosamine Kinase-Small Nuclear Ribonucleoprotein Polypeptide N Interaction Promotes Axodendritic Branching in Neurons via Dynein-Mediated Microtubule Transport.1
375114332023N-Acetylglucosamine Kinase-Small Nuclear Ribonucleoprotein Polypeptide N Interaction Promotes Axodendritic Branching in Neurons via Dynein-Mediated Microtubule Transport.1
348446672021Glutamine deprivation triggers NAGK-dependent hexosamine salvage.25
348446672021Glutamine deprivation triggers NAGK-dependent hexosamine salvage.25
328960842020Implementation of the plasma MYCN/NAGK ratio to detect MYCN amplification in patients with neuroblastoma.2
333744562020N-Acetyl-D-Glucosamine Kinase Interacts with NudC and Lis1 in Dynein Motor Complex and Promotes Cell Migration.6
328960842020Implementation of the plasma MYCN/NAGK ratio to detect MYCN amplification in patients with neuroblastoma.2
333744562020N-Acetyl-D-Glucosamine Kinase Interacts with NudC and Lis1 in Dynein Motor Complex and Promotes Cell Migration.6
309045942019Developmental regulation of Wnt signaling by Nagk and the UDP-GlcNAc salvage pathway.11
309045942019Developmental regulation of Wnt signaling by Nagk and the UDP-GlcNAc salvage pathway.11
276466882016N-Acetyl-D-Glucosamine Kinase Interacts with Dynein-Lis1-NudE1 Complex and Regulates Cell Division.7
276466882016N-Acetyl-D-Glucosamine Kinase Interacts with Dynein-Lis1-NudE1 Complex and Regulates Cell Division.7
259216062015N-acetyl-D-glucosamine kinase is a component of nuclear speckles and paraspeckles.13

Citation

Dessen P

NAGK (N-acetylglucosamine kinase)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70673/css/img/logo-atlas-4.svg