OPN4 (opsin 4)

OPN4 (opsin 4)

2014-11-01 Affiliation

Identity

HGNC

LOCATION

10q23.2

LOCUSID

ALIAS

MOP

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 94233
MIM: 606665
HGNC: 14449
Ensembl: ENSG00000122375

Variants:

dbSNP: 94233
ClinVar: 94233
TCGA: ENSG00000122375
COSMIC: OPN4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000122375	ENST00000241891	Q9UHM6
ENSG00000122375	ENST00000372071	Q9UHM6
ENSG00000122375	ENST00000443292	C9JWU6

Expression (GTEx)

0

1

2

3

4

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Opsins	REACTOME	R-HSA-419771
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (q) signalling events	REACTOME	R-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
35562405	2022	Melanopsin (Opn4) is an oncogene in cutaneous melanoma.	6
35637236	2022	The melanopsin-mediated pupil response is reduced in idiopathic hypersomnia with long sleep time.	3
35562405	2022	Melanopsin (Opn4) is an oncogene in cutaneous melanoma.	6
35637236	2022	The melanopsin-mediated pupil response is reduced in idiopathic hypersomnia with long sleep time.	3
33445464	2021	Association of P10L Polymorphism in Melanopsin Gene with Chronic Insomnia in Mexicans.	0
34035222	2021	Exosomal S100A4 derived from highly metastatic hepatocellular carcinoma cells promotes metastasis by activating STAT3.	45
33445464	2021	Association of P10L Polymorphism in Melanopsin Gene with Chronic Insomnia in Mexicans.	0
34035222	2021	Exosomal S100A4 derived from highly metastatic hepatocellular carcinoma cells promotes metastasis by activating STAT3.	45
31989708	2020	OPN4 belongs to the photosensitive system of the human skin.	8
32269074	2020	Targeting Opsin4/Melanopsin with a Novel Small Molecule Suppresses PKC/RAF/MEK/ERK Signaling and Inhibits Lung Adenocarcinoma Progression.	4
32645331	2020	Melanopsin mediates UVA-dependent modulation of proliferation, pigmentation, apoptosis, and molecular clock in normal and malignant melanocytes.	13
31989708	2020	OPN4 belongs to the photosensitive system of the human skin.	8
32269074	2020	Targeting Opsin4/Melanopsin with a Novel Small Molecule Suppresses PKC/RAF/MEK/ERK Signaling and Inhibits Lung Adenocarcinoma Progression.	4
32645331	2020	Melanopsin mediates UVA-dependent modulation of proliferation, pigmentation, apoptosis, and molecular clock in normal and malignant melanocytes.	13
31110303	2019	A quantitative analysis of the contribution of melanopsin to brightness perception.	22

Citation

Dessen P

OPN4 (opsin 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71135/css/js/js/lib/popper.js