OPN5 (opsin 5)

2014-11-01  

Identity

HGNC
OPN5
LOCATION
6p12.3
LOCUSID
221391
ALIAS
GPR136,GRP136,PGR12,TMEM13

Other Information

Locus ID:

NCBI: 221391
MIM: 609042
HGNC: 19992
Ensembl: ENSG00000124818

Variants:

dbSNP: 221391
ClinVar: 221391
TCGA: ENSG00000124818
COSMIC: OPN5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124818ENST00000371211Q6U736
ENSG00000124818ENST00000393699J3KPQ2
ENSG00000124818ENST00000489301D6RDV4
ENSG00000124818ENST00000638973Q6U736

Expression (GTEx)

0
1
2
3
4
5
6
7
8
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
OpsinsREACTOMER-HSA-419771
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
retina
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
324143242020Neuropsin in mental health.3
324143242020Neuropsin in mental health.3
286365782017Human neuropsin gene in depression.7
286365782017Human neuropsin gene in depression.7
244030722014Evolution of mammalian Opn5 as a specialized UV-absorbing pigment by a single amino acid mutation.38
246146392014[Neuropsin signaling as a novel therapeutic target of schizophrenia].0
249419102014Light-induced rapid Ca²⁺ response and MAPK phosphorylation in the cells heterologously expressing human OPN5.11
244030722014Evolution of mammalian Opn5 as a specialized UV-absorbing pigment by a single amino acid mutation.38
246146392014[Neuropsin signaling as a novel therapeutic target of schizophrenia].0
249419102014Light-induced rapid Ca²⁺ response and MAPK phosphorylation in the cells heterologously expressing human OPN5.11
220433192011UV-sensitive photoreceptor protein OPN5 in humans and mice.89
220433192011UV-sensitive photoreceptor protein OPN5 in humans and mice.89
183543912008Genetic variations of human neuropsin gene and psychiatric disorders: polymorphism screening and possible association with bipolar disorder and cognitive functions.16
183543912008Genetic variations of human neuropsin gene and psychiatric disorders: polymorphism screening and possible association with bipolar disorder and cognitive functions.16

Citation

Dessen P

OPN5 (opsin 5)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71136/js/css/template-nav.css