OSBPL3 (oxysterol binding protein like 3)

2014-11-01  

Identity

HGNC
OSBPL3
LOCATION
7p15.3
LOCUSID
26031
ALIAS
ORP-3,ORP3,OSBP3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 26031
MIM: 606732
HGNC: 16370
Ensembl: ENSG00000070882

Variants:

dbSNP: 26031
ClinVar: 26031
TCGA: ENSG00000070882
COSMIC: OSBPL3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000070882ENST00000313367Q9H4L5
ENSG00000070882ENST00000396429Q9H4L5
ENSG00000070882ENST00000396431Q9H4L5
ENSG00000070882ENST00000409069Q9H4L5
ENSG00000070882ENST00000409452Q9H4L5
ENSG00000070882ENST00000409555Q9H4L5
ENSG00000070882ENST00000409759Q9H4L5
ENSG00000070882ENST00000409863Q9H4L5
ENSG00000070882ENST00000415162C9JZ19
ENSG00000070882ENST00000415952C9J8P4
ENSG00000070882ENST00000441059C9JEF2

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Bile acid and bile salt metabolismREACTOMER-HSA-194068
Synthesis of bile acids and bile saltsREACTOMER-HSA-192105

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
367811182023Oxysterol-binding protein-like 3 is a novel target gene of peroxisome proliferator-activated receptor γ in fatty liver disease.0
375506052023Prognostic and biological function value of OSBPL3 in colorectal cancer analyzed by multi-omic data analysis.0
377401302023Loss of ORP3 induces aneuploidy and promotes bladder cancer cell invasion through deregulated microtubule and actin dynamics.1
367811182023Oxysterol-binding protein-like 3 is a novel target gene of peroxisome proliferator-activated receptor γ in fatty liver disease.0
375506052023Prognostic and biological function value of OSBPL3 in colorectal cancer analyzed by multi-omic data analysis.0
377401302023Loss of ORP3 induces aneuploidy and promotes bladder cancer cell invasion through deregulated microtubule and actin dynamics.1
365178052022The relationships of OSBPL3 expression with KI-67 expression and KRAS mutations in CRC: implications for diagnosis and prognosis.4
365178052022The relationships of OSBPL3 expression with KI-67 expression and KRAS mutations in CRC: implications for diagnosis and prognosis.4
338571822021Structure of human ORP3 ORD reveals conservation of a key function and ligand specificity in OSBP-related proteins.7
345841272021Oxysterol binding protein-like 3 (OSBPL3) is a novel driver gene that promotes tumor growth in part through R-Ras/Akt signaling in gastric cancer.12
338571822021Structure of human ORP3 ORD reveals conservation of a key function and ligand specificity in OSBP-related proteins.7
345841272021Oxysterol binding protein-like 3 (OSBPL3) is a novel driver gene that promotes tumor growth in part through R-Ras/Akt signaling in gastric cancer.12
316592552020Aneuploidy-inducing gene knockdowns overlap with cancer mutations and identify Orp3 as a B-cell lymphoma suppressor.11
322342132020Calcium-stimulated disassembly of focal adhesions mediated by an ORP3/IQSec1 complex.30
328195572020The crystal structure of ORP3 reveals the conservative PI4P binding pattern.5

Citation

Dessen P

OSBPL3 (oxysterol binding protein like 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71553/css/js/lib/js/web-card-gene.js