OTOS (otospiralin)

2014-11-01 Affiliation

Identity

HGNC

OTOS

LOCATION

2q37.3

LOCUSID

150677

ALIAS

OTOSP

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 150677
MIM: 607877
HGNC: 22644
Ensembl: ENSG00000178602

Variants:

dbSNP: 150677
ClinVar: 150677
TCGA: ENSG00000178602
COSMIC: OTOS

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000178602	ENST00000319460	Q8NHW6
ENSG00000178602	ENST00000391989	Q8NHW6

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA445062	Neoplasms	Disease	ClinicalAnnotation	associated		PD	25410892, 31666714
PA449014	cisplatin	Chemical	ClinicalAnnotation	associated		PD	25410892, 31666714

References

Pubmed ID	Year	Title	Citations
25410892	2014	Genetic variation in Otos is associated with cisplatin-induced ototoxicity.	0
25410892	2014	Genetic variation in Otos is associated with cisplatin-induced ototoxicity.	0
12687421	2003	Gene structure, chromosomal localization, and mutation screening of the human gene for the inner ear protein otospiralin.	1
12687421	2003	Gene structure, chromosomal localization, and mutation screening of the human gene for the inner ear protein otospiralin.	1

Citation

Dessen P

OTOS (otospiralin)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71579/css/lib/css/card-gene.css