PEX19 (peroxisomal biogenesis factor 19)

2014-11-01  

Identity

HGNC
PEX19
LOCATION
1q23.2
LOCUSID
5824
ALIAS
D1S2223E,HK33,PBD12A,PMP1,PMPI,PXF,PXMP1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5824
MIM: 600279
HGNC: 9713
Ensembl: ENSG00000162735

Variants:

dbSNP: 5824
ClinVar: 5824
TCGA: ENSG00000162735
COSMIC: PEX19

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162735ENST00000368072P40855
ENSG00000162735ENST00000368072A0A0S2Z497
ENSG00000162735ENST00000392220Q5QNY5
ENSG00000162735ENST00000462644E9PS71
ENSG00000162735ENST00000472750E9PPB4
ENSG00000162735ENST00000495624H0YDY4
ENSG00000162735ENST00000532643B7Z8B3

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
PeroxisomeKEGGko04146
PeroxisomeKEGGhsa04146
Transmembrane transport of small moleculesREACTOMER-HSA-382551
ABC-family proteins mediated transportREACTOMER-HSA-382556
ABC transporters in lipid homeostasisREACTOMER-HSA-1369062

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
352158462022Dengue and Zika Virus Capsid Proteins Contain a Common PEX19-Binding Motif.1
352158462022Dengue and Zika Virus Capsid Proteins Contain a Common PEX19-Binding Motif.1
341082652021Viperin interacts with PEX19 to mediate peroxisomal augmentation of the innate antiviral response.2
341082652021Viperin interacts with PEX19 to mediate peroxisomal augmentation of the innate antiviral response.2
307760932019The peroxisome biogenesis factors Pex3 and Pex19: multitasking proteins with disputed functions.27
307760932019The peroxisome biogenesis factors Pex3 and Pex19: multitasking proteins with disputed functions.27
292822812018Unbalanced lipolysis results in lipotoxicity and mitochondrial damage in peroxisome-deficient Pex19 mutants.20
293964262018The peroxisome biogenesis factors posttranslationally target reticulon homology domain-containing proteins to the endoplasmic reticulum membrane.14
295009182018Intracellular communication between lipid droplets and peroxisomes: the Janus face of PEX19.10
292822812018Unbalanced lipolysis results in lipotoxicity and mitochondrial damage in peroxisome-deficient Pex19 mutants.20
293964262018The peroxisome biogenesis factors posttranslationally target reticulon homology domain-containing proteins to the endoplasmic reticulum membrane.14
295009182018Intracellular communication between lipid droplets and peroxisomes: the Janus face of PEX19.10
282815582017Allosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor PEX19.22
282815582017Allosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor PEX19.22
272955532016Peroxin-dependent targeting of a lipid-droplet-destined membrane protein to ER subdomains.51

Citation

Dessen P

PEX19 (peroxisomal biogenesis factor 19)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71839/haematological-explorer/favicon/favicon-16x16.png