POLR2M (RNA polymerase II subunit M)

2014-11-01  

Identity

HGNC
POLR2M
LOCATION
15q21.3
LOCUSID
81488
ALIAS
GCOM1,GRINL1A,Gdown,Gdown1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 81488
MIM: 606485
HGNC: 14862
Ensembl: ENSG00000255529

Variants:

dbSNP: 81488
ClinVar: 81488
TCGA: ENSG00000255529
COSMIC: POLR2M

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000255529ENST00000299638P0CAP2
ENSG00000255529ENST00000380557P0CAP2
ENSG00000255529ENST00000464277E9PP13
ENSG00000255529ENST00000482852P0CAP2
ENSG00000255529ENST00000494490E9PP13
ENSG00000255529ENST00000649091Q6EEV4
ENSG00000255529ENST00000649091L0R6H6

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
347411192022The tumor suppressor MIR139 is silenced by POLR2M to promote AML oncogenesis.7
350489792022Nuclear export restricts Gdown1 to a mitotic function.4
347411192022The tumor suppressor MIR139 is silenced by POLR2M to promote AML oncogenesis.7
350489792022Nuclear export restricts Gdown1 to a mitotic function.4
277168202016Gdown1 Associates Efficiently with RNA Polymerase II after Promoter Clearance and Displaces TFIIF during Transcript Elongation.7
277168202016Gdown1 Associates Efficiently with RNA Polymerase II after Promoter Clearance and Displaces TFIIF during Transcript Elongation.7
245960852014Functional interactions of the RNA polymerase II-interacting proteins Gdown1 and TFIIF.6
246342142014Regulation of RNA polymerase II termination by phosphorylation of Gdown1.15
245960852014Functional interactions of the RNA polymerase II-interacting proteins Gdown1 and TFIIF.6
246342142014Regulation of RNA polymerase II termination by phosphorylation of Gdown1.15
222443312012Functional association of Gdown1 with RNA polymerase II poised on human genes.85
222443322012Transcriptional regulation by Pol II(G) involving mediator and competitive interactions of Gdown1 and TFIIF with Pol II.44
222443312012Functional association of Gdown1 with RNA polymerase II poised on human genes.85
222443322012Transcriptional regulation by Pol II(G) involving mediator and competitive interactions of Gdown1 and TFIIF with Pol II.44
204122992010Structural basis for the interaction between dynein light chain 1 and the glutamate channel homolog GRINL1A.5

Citation

Dessen P

POLR2M (RNA polymerase II subunit M)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72054/cancer-prone-explorer/css/card-gene.css