ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2)

2003-06-01 Affiliation

Identity

HGNC

ATP2A2

LOCATION

12q24.11

LOCUSID

488

ALIAS

ATP2B,DAR,DD,SERCA2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 488
MIM: 108740
HGNC: 812
Ensembl: ENSG00000174437

Variants:

dbSNP: 488
ClinVar: 488
TCGA: ENSG00000174437
COSMIC: ATP2A2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000174437	ENST00000308664	P16615
ENSG00000174437	ENST00000377685	J3QSY6
ENSG00000174437	ENST00000539276	P16615
ENSG00000174437	ENST00000539276	A0A0S2Z3L2
ENSG00000174437	ENST00000548169	H7C5W9
ENSG00000174437	ENST00000552636	F8W1Z7
ENSG00000174437	ENST00000553144	A0A0C4DH86

Expression (GTEx)

500

1000

1500

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Calcium signaling pathway	KEGG	ko04020
Alzheimer's disease	KEGG	ko05010
Calcium signaling pathway	KEGG	hsa04020
Alzheimer's disease	KEGG	hsa05010
Cardiac muscle contraction	KEGG	hsa04260
Cardiac muscle contraction	KEGG	ko04260
Hypertrophic cardiomyopathy (HCM)	KEGG	ko05410
Hypertrophic cardiomyopathy (HCM)	KEGG	hsa05410
Arrhythmogenic right ventricular cardiomyopathy (ARVC)	KEGG	ko05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC)	KEGG	hsa05412
Dilated cardiomyopathy	KEGG	ko05414
Dilated cardiomyopathy	KEGG	hsa05414
Pancreatic secretion	KEGG	ko04972
Pancreatic secretion	KEGG	hsa04972
Adrenergic signaling in cardiomyocytes	KEGG	hsa04261
Adrenergic signaling in cardiomyocytes	KEGG	ko04261
Thyroid hormone signaling pathway	KEGG	hsa04919
cGMP-PKG signaling pathway	KEGG	hsa04022
cGMP-PKG signaling pathway	KEGG	ko04022
cAMP signaling pathway	KEGG	hsa04024
cAMP signaling pathway	KEGG	ko04024
Hemostasis	REACTOME	R-HSA-109582
Platelet homeostasis	REACTOME	R-HSA-418346
Platelet calcium homeostasis	REACTOME	R-HSA-418360
Reduction of cytosolic Ca++ levels	REACTOME	R-HSA-418359
Signal Transduction	REACTOME	R-HSA-162582
Signaling by NOTCH	REACTOME	R-HSA-157118
Pre-NOTCH Expression and Processing	REACTOME	R-HSA-1912422
Pre-NOTCH Processing in Golgi	REACTOME	R-HSA-1912420
Muscle contraction	REACTOME	R-HSA-397014
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
Ion channel transport	REACTOME	R-HSA-983712
Ion transport by P-type ATPases	REACTOME	R-HSA-936837
Cardiac conduction	REACTOME	R-HSA-5576891
Ion homeostasis	REACTOME	R-HSA-5578775

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA448871	celecoxib	Chemical	Pathway	associated			22336956

References

Pubmed ID	Year	Title	Citations
22679139	2012	Modulation of cardiac contractility by the phospholamban/SERCA2a regulatome.	149
21900893	2011	SUMO1-dependent modulation of SERCA2a in heart failure.	118
18591429	2008	SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production.	105
15215242	2004	Enrichment of endoplasmic reticulum with cholesterol inhibits sarcoplasmic-endoplasmic reticulum calcium ATPase-2b activity in parallel with increased order of membrane lipids: implications for depletion of endoplasmic reticulum calcium stores and apoptosis in cholesterol-loaded macrophages.	92
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
19541629	2009	Diminished sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) expression contributes to airway remodelling in bronchial asthma.	57
23843619	2013	Palmitoylation is the switch that assigns calnexin to quality control or ER Ca2+ signaling.	52
22240811	2012	PPAR-γ activation restores pancreatic islet SERCA2 levels and prevents β-cell dysfunction under conditions of hyperglycemic and cytokine stress.	47
23055483	2012	Age-dependent microRNA control of synaptic plasticity in 22q11 deletion syndrome and schizophrenia.	44
17526652	2007	Histidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPase.	41

Citation

Dessen P

ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/723/atp2a2-(atpase-sarcoplasmic-endoplasmic-reticulum-ca2+-transporting-2)