RAP1GAP2 (RAP1 GTPase activating protein 2)

2014-11-01  

Identity

HGNC
LOCATION
17p13.3
LOCUSID
ALIAS
GARNL4,RAP1GA3
FUSION GENES

Other Information

Locus ID:

NCBI: 23108
MIM: 618714
HGNC: 29176
Ensembl: ENSG00000132359

Variants:

dbSNP: 23108
ClinVar: 23108
TCGA: ENSG00000132359
COSMIC: RAP1GAP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132359ENST00000254695Q684P5
ENSG00000132359ENST00000366401Q684P5
ENSG00000132359ENST00000540393Q684P5
ENSG00000132359ENST00000542807Q684P5
ENSG00000132359ENST00000637138A0A1B0GV05

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Rap1 signallingREACTOMER-HSA-392517

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443450AsthmaDiseaseLiterature, MultilinkAnnotationassociated24824216

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
195285392009Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets.20
195285392009Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets.20
180396622008Cyclic nucleotide-dependent protein kinases inhibit binding of 14-3-3 to the GTPase-activating protein Rap1GAP2 in platelets.14
180396622008Cyclic nucleotide-dependent protein kinases inhibit binding of 14-3-3 to the GTPase-activating protein Rap1GAP2 in platelets.14
156322032005Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets.35
156322032005Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets.35

Citation

Dessen P

RAP1GAP2 (RAP1 GTPase activating protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72486/deep-insight-explorer/css/template-nav.css