REEP2 (receptor accessory protein 2)

2014-11-01  

Identity

HGNC
REEP2
LOCATION
5q31.2
LOCUSID
51308
ALIAS
C5orf19,SGC32445,SPG72,Yip2d

Other Information

Locus ID:

NCBI: 51308
MIM: 609347
HGNC: 17975
Ensembl: ENSG00000132563

Variants:

dbSNP: 51308
ClinVar: 51308
TCGA: ENSG00000132563
COSMIC: REEP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132563ENST00000254901Q9BRK0
ENSG00000132563ENST00000378339Q9BRK0
ENSG00000132563ENST00000378339A8K3D2
ENSG00000132563ENST00000506158B4DE60
ENSG00000132563ENST00000507511D6RB42
ENSG00000132563ENST00000512126H0YAC5
ENSG00000132563ENST00000613650A0A087WV88

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
Olfactory Signaling PathwayREACTOMER-HSA-381753

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
243886632014Loss of association of REEP2 with membranes leads to hereditary spastic paraplegia.25
209439182010REEP2 enhances sweet receptor function by recruitment to lipid rafts.19
243555972014REEP1 and REEP2 proteins are preferentially expressed in neuronal and neuronal-like exocytotic tissues.13

Citation

Dessen P

REEP2 (receptor accessory protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72569/reep2