RIC8A (RIC8 guanine nucleotide exchange factor A)

2014-11-01  

Identity

HGNC
RIC8A
LOCATION
11p15.5
LOCUSID
60626
ALIAS
RIC8
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 60626
MIM: 609146
HGNC: 29550
Ensembl: ENSG00000177963

Variants:

dbSNP: 60626
ClinVar: 60626
TCGA: ENSG00000177963
COSMIC: RIC8A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177963ENST00000325207Q9NPQ8
ENSG00000177963ENST00000524854H0YE35
ENSG00000177963ENST00000526104Q9NPQ8
ENSG00000177963ENST00000526982E9PLE5
ENSG00000177963ENST00000527468E9PMP0
ENSG00000177963ENST00000527696Q9NPQ8
ENSG00000177963ENST00000527728H0YEN0
ENSG00000177963ENST00000528357E9PI04
ENSG00000177963ENST00000529275H0YC88
ENSG00000177963ENST00000530889E9PSI0
ENSG00000177963ENST00000626818E9PLE5

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
340396242021circPDE4B prevents articular cartilage degeneration and promotes repair by acting as a scaffold for RIC8A and MID1.46
340396242021circPDE4B prevents articular cartilage degeneration and promotes repair by acting as a scaffold for RIC8A and MID1.46
321262082020Structures of Gα Proteins in Complex with Their Chaperone Reveal Quality Control Mechanisms.13
321262082020Structures of Gα Proteins in Complex with Their Chaperone Reveal Quality Control Mechanisms.13
298440552018Dual phosphorylation of Ric-8A enhances its ability to mediate G protein α subunit folding and to stimulate guanine nucleotide exchange.12
298440552018Dual phosphorylation of Ric-8A enhances its ability to mediate G protein α subunit folding and to stimulate guanine nucleotide exchange.12
254805672015Activator of G protein signaling 3 forms a complex with resistance to inhibitors of cholinesterase-8A without promoting nucleotide exchange on Gα(i3).1
254805672015Activator of G protein signaling 3 forms a complex with resistance to inhibitors of cholinesterase-8A without promoting nucleotide exchange on Gα(i3).1
244661962014Resistance to inhibitors of cholinesterase (Ric)-8A and Gαi contribute to cytokinesis abscission by controlling vacuolar protein-sorting (Vps)34 activity.10
250748112014The guanine-exchange factor Ric8a binds to the Ca²⁺ sensor NCS-1 to regulate synapse number and neurotransmitter release.16
244661962014Resistance to inhibitors of cholinesterase (Ric)-8A and Gαi contribute to cytokinesis abscission by controlling vacuolar protein-sorting (Vps)34 activity.10
250748112014The guanine-exchange factor Ric8a binds to the Ca²⁺ sensor NCS-1 to regulate synapse number and neurotransmitter release.16
236653272013Ubiquitination of the heterotrimeric G protein α subunits Gαi2 and Gαq is prevented by the guanine nucleotide exchange factor Ric-8A.11
236653272013Ubiquitination of the heterotrimeric G protein α subunits Gαi2 and Gαq is prevented by the guanine nucleotide exchange factor Ric-8A.11
223841812012NCAM180 regulates Ric8A membrane localization and potentiates β-adrenergic response.3

Citation

Dessen P

RIC8A (RIC8 guanine nucleotide exchange factor A)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72640/favicon/css/card-gene.css