SLC1A6 (solute carrier family 1 member 6)

2014-11-01  

Identity

HGNC
SLC1A6
LOCATION
19p13.12
LOCUSID
6511
ALIAS
EAAT4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6511
MIM: 600637
HGNC: 10944
Ensembl: ENSG00000105143

Variants:

dbSNP: 6511
ClinVar: 6511
TCGA: ENSG00000105143
COSMIC: SLC1A6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105143ENST00000221742P48664
ENSG00000105143ENST00000430939E7EV13
ENSG00000105143ENST00000544886P48664
ENSG00000105143ENST00000594383M0R1V3
ENSG00000105143ENST00000595863M0QY32
ENSG00000105143ENST00000597262M0R106
ENSG00000105143ENST00000598504P48664
ENSG00000105143ENST00000599636M0R2V7
ENSG00000105143ENST00000600144M0R063
ENSG00000105143ENST00000601761M0R0B5

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Release CycleREACTOMER-HSA-112310
Glutamate Neurotransmitter Release CycleREACTOMER-HSA-210500
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
279785272016Up-Regulation of Excitatory Amino Acid Transporters EAAT3 and EAAT4 by Lithium Sensitive Glycogen Synthase Kinase GSK3ß.5
279785272016Up-Regulation of Excitatory Amino Acid Transporters EAAT3 and EAAT4 by Lithium Sensitive Glycogen Synthase Kinase GSK3ß.5
224242432013Gene expression of glutamate transporters SLC1A1, SLC1A3 and SLC1A6 in the cerebellar subregions of elderly schizophrenia patients and effects of antipsychotic treatment.7
224242432013Gene expression of glutamate transporters SLC1A1, SLC1A3 and SLC1A6 in the cerebellar subregions of elderly schizophrenia patients and effects of antipsychotic treatment.7
223027962012Neuronal glutamate transporters regulate glial excitatory transmission.17
223027962012Neuronal glutamate transporters regulate glial excitatory transmission.17
215720472011Substrate-dependent gating of anion channels associated with excitatory amino acid transporter 4.15
215720472011Substrate-dependent gating of anion channels associated with excitatory amino acid transporter 4.15
204244732010L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.0
205195052010A conserved aspartate determines pore properties of anion channels associated with excitatory amino acid transporter 4 (EAAT4).22
204244732010L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.0
205195052010A conserved aspartate determines pore properties of anion channels associated with excitatory amino acid transporter 4 (EAAT4).22
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.39
191561682009Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.49
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.39

Citation

Dessen P

SLC1A6 (solute carrier family 1 member 6)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73312/gene-explorer/js/template.js