TBKBP1 (TBK1 binding protein 1)

2014-11-01  

Identity

HGNC
TBKBP1
LOCATION
17q21.32
LOCUSID
9755
ALIAS
ProSAPiP2,SINTBAD

Other Information

Locus ID:

NCBI: 9755
MIM: 608476
HGNC: 30140
Ensembl: ENSG00000198933

Variants:

dbSNP: 9755
ClinVar: 9755
TCGA: ENSG00000198933
COSMIC: TBKBP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198933ENST00000361722A7MCY6
ENSG00000198933ENST00000537587F5H1U4
ENSG00000198933ENST00000578982J3KS71
ENSG00000198933ENST00000622396A7MCY6

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RIG-I-like receptor signaling pathwayKEGGko04622
RIG-I-like receptor signaling pathwayKEGGhsa04622

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
355456832022A multi-step genomic approach prioritized TBKBP1 gene as relevant for multiple sclerosis susceptibility.2
355456832022A multi-step genomic approach prioritized TBKBP1 gene as relevant for multiple sclerosis susceptibility.2
315230442020Analysis of 47 Non-MHC Ankylosing Spondylitis Susceptibility Loci Regarding Associated Variants across Whites and Han Chinese.2
315230442020Analysis of 47 Non-MHC Ankylosing Spondylitis Susceptibility Loci Regarding Associated Variants across Whites and Han Chinese.2
308534022019The Cargo Receptor NDP52 Initiates Selective Autophagy by Recruiting the ULK Complex to Cytosol-Invading Bacteria.144
317923812019TBKBP1 and TBK1 form a growth factor signalling axis mediating immunosuppression and tumourigenesis.35
308534022019The Cargo Receptor NDP52 Initiates Selective Autophagy by Recruiting the ULK Complex to Cytosol-Invading Bacteria.144
317923812019TBKBP1 and TBK1 form a growth factor signalling axis mediating immunosuppression and tumourigenesis.35
254942922015Analysis of clinical indexes and RUNX3, TBKBP1, PPARGC1B polymorphisms in Chinese Han patients with ankylosing spondylitis.5
254942922015Analysis of clinical indexes and RUNX3, TBKBP1, PPARGC1B polymorphisms in Chinese Han patients with ankylosing spondylitis.5
232863852013Identification of proteins that interact with TANK binding kinase 1 and testing for mutations associated with glaucoma.3
236378482013Analysis of PPARGC1B, RUNX3 and TBKBP1 polymorphisms in Chinese Han patients with ankylosing spondylitis: a case-control study.9
232863852013Identification of proteins that interact with TANK binding kinase 1 and testing for mutations associated with glaucoma.3
236378482013Analysis of PPARGC1B, RUNX3 and TBKBP1 polymorphisms in Chinese Han patients with ankylosing spondylitis: a case-control study.9
175687782007SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK.87

Citation

Dessen P

TBKBP1 (TBK1 binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74544/css/card-gene.css