TCERG1 (transcription elongation regulator 1)

2014-11-01  

Identity

HGNC
TCERG1
LOCATION
5q32
LOCUSID
10915
ALIAS
CA150,TAF2S,Urn1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10915
MIM: 605409
HGNC: 15630
Ensembl: ENSG00000113649

Variants:

dbSNP: 10915
ClinVar: 10915
TCGA: ENSG00000113649
COSMIC: TCERG1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113649ENST00000296702O14776
ENSG00000113649ENST00000394421O14776
ENSG00000113649ENST00000549332G3V220

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
154568882004The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo.37
170185622007Replication of twelve association studies for Huntington's disease residual age of onset in large Venezuelan kindreds.31
167828862006Human transcription elongation factor CA150 localizes to splicing factor-rich nuclear speckles and assembles transcription and splicing components into complexes through its amino and carboxyl regions.21
221589662012TCERG1 regulates alternative splicing of the Bcl-x gene by modulating the rate of RNA polymerase II transcription.21
181874142008Identification of the cellular targets of the transcription factor TCERG1 reveals a prevalent role in mRNA processing.18
128211792003Modulation of age at onset in Huntington's disease and spinocerebellar ataxia type 2 patients originated from eastern India.13
202151162010Differential effects of sumoylation on transcription and alternative splicing by transcription elongation regulator 1 (TCERG1).12
234366542013Specific interaction of the transcription elongation regulator TCERG1 with RNA polymerase II requires simultaneous phosphorylation at Ser2, Ser5, and Ser7 within the carboxyl-terminal domain repeat.8
241650372013Transcription elongation regulator 1 (TCERG1) regulates competent RNA polymerase II-mediated elongation of HIV-1 transcription and facilitates efficient viral replication.8
166447322006Identification of a co-repressor that inhibits the transcriptional and growth-arrest activities of CCAAT/enhancer-binding protein alpha.6

Citation

Dessen P

TCERG1 (transcription elongation regulator 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74576/tcerg1