THOC2 (THO complex 2)

2014-11-01  

Identity

HGNC
LOCATION
Xq25
LOCUSID
ALIAS
CXorf3,MRX12,MRX35,THO2,dJ506G2.1,hTREX120
FUSION GENES

Other Information

Locus ID:

NCBI: 57187
MIM: 300395
HGNC: 19073
Ensembl: ENSG00000125676

Variants:

dbSNP: 57187
ClinVar: 57187
TCGA: ENSG00000125676
COSMIC: THOC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125676ENST00000245838Q8NI27
ENSG00000125676ENST00000355725Q8NI27
ENSG00000125676ENST00000416618B7ZBA0
ENSG00000125676ENST00000432353H7C477
ENSG00000125676ENST00000433883F2Z2V2
ENSG00000125676ENST00000438358H0Y815
ENSG00000125676ENST00000441692H0Y7U4
ENSG00000125676ENST00000448128H0Y594
ENSG00000125676ENST00000455053B7ZB98
ENSG00000125676ENST00000491737A0A0C4DG98
ENSG00000125676ENST00000618150Q8NI27

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
RNA transportKEGGko03013
RNA transportKEGGhsa03013
THC complexKEGGhsa_M00405
TREX complexKEGGhsa_M00406
THC complexKEGGM00405
TREX complexKEGGM00406
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Transcription TerminationREACTOMER-HSA-73856
Cleavage of Growing Transcript in the Termination RegionREACTOMER-HSA-109688
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA 3'-end processingREACTOMER-HSA-72187
Transport of Mature Transcript to CytoplasmREACTOMER-HSA-72202
Transport of Mature mRNA derived from an Intron-Containing TranscriptREACTOMER-HSA-159236

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
159988062005Recruitment of the human TREX complex to mRNA during splicing.174
261664802015THOC2 Mutations Implicate mRNA-Export Pathway in X-Linked Intellectual Disability.12
298511912018Severe neurocognitive and growth disorders due to variation in THOC2, an essential component of nuclear mRNA export machinery.3
316806232019Knockdown THOC2 suppresses the proliferation and invasion of melanoma.0

Citation

Dessen P

THOC2 (THO complex 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74679/thoc2