TRMT10C (tRNA methyltransferase 10C, mitochondrial RNase P subunit)

2014-11-01 Affiliation

Identity

HGNC

TRMT10C

LOCATION

3q12.3

LOCUSID

54931

ALIAS

COXPD30,HNYA,MRPP1,RG9MTD1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 54931
MIM: 615423
HGNC: 26022
Ensembl: ENSG00000174173

Variants:

dbSNP: 54931
ClinVar: 54931
TCGA: ENSG00000174173
COSMIC: TRMT10C

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000174173	ENST00000309922	Q7L0Y3
ENSG00000174173	ENST00000495642	C9JVB6

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Gene Expression	REACTOME	R-HSA-74160
tRNA processing	REACTOME	R-HSA-72306
tRNA processing in the mitochondrion	REACTOME	R-HSA-6785470
tRNA modification in the mitochondrion	REACTOME	R-HSA-6787450
rRNA processing	REACTOME	R-HSA-72312
rRNA processing in the mitochondrion	REACTOME	R-HSA-8868766

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
33380464	2021	Disease-associated mutations in mitochondrial precursor tRNAs affect binding, m1R9 methylation, and tRNA processing by mtRNase P.	8
34489609	2021	Structural basis of RNA processing by human mitochondrial RNase P.	32
33380464	2021	Disease-associated mutations in mitochondrial precursor tRNAs affect binding, m1R9 methylation, and tRNA processing by mtRNase P.	8
34489609	2021	Structural basis of RNA processing by human mitochondrial RNase P.	32
32833542	2020	m(1)A Regulator TRMT10C Predicts Poorer Survival and Contributes to Malignant Behavior in Gynecological Cancers.	18
32833542	2020	m(1)A Regulator TRMT10C Predicts Poorer Survival and Contributes to Malignant Behavior in Gynecological Cancers.	18
29880640	2018	Structural insight into the human mitochondrial tRNA purine N1-methyltransferase and ribonuclease P complexes.	18
29880640	2018	Structural insight into the human mitochondrial tRNA purine N1-methyltransferase and ribonuclease P complexes.	18
29040705	2017	The MRPP1/MRPP2 complex is a tRNA-maturation platform in human mitochondria.	29
29040705	2017	The MRPP1/MRPP2 complex is a tRNA-maturation platform in human mitochondria.	29
27132592	2016	Recessive Mutations in TRMT10C Cause Defects in Mitochondrial RNA Processing and Multiple Respiratory Chain Deficiencies.	55
27132592	2016	Recessive Mutations in TRMT10C Cause Defects in Mitochondrial RNA Processing and Multiple Respiratory Chain Deficiencies.	55
23755257	2013	The amyloid-β-SDR5C1(ABAD) interaction does not mediate a specific inhibition of mitochondrial RNase P.	4
23755257	2013	The amyloid-β-SDR5C1(ABAD) interaction does not mediate a specific inhibition of mitochondrial RNase P.	4
21857155	2011	RNA processing in human mitochondria.	128

Citation

Dessen P

TRMT10C (tRNA methyltransferase 10C, mitochondrial RNase P subunit)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75195/js/lib/css/template-nav.css