TTI1 (TELO2 interacting protein 1)

2014-11-01  

Identity

HGNC
LOCATION
20q11.23
LOCUSID
ALIAS
KIAA0406,smg-10
FUSION GENES

Other Information

Locus ID:

NCBI: 9675
MIM: 614425
HGNC: 29029
Ensembl: ENSG00000101407

Variants:

dbSNP: 9675
ClinVar: 9675
TCGA: ENSG00000101407
COSMIC: TTI1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101407ENST00000373447O43156
ENSG00000101407ENST00000373448O43156
ENSG00000101407ENST00000449821O43156
ENSG00000101407ENST00000620381A0A087WT32

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
mTOR signaling pathwayKEGGko04150
mTOR signaling pathwayKEGGhsa04150

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
364031972023TTI1 promotes non-small-cell lung cancer progression by regulating the mTOR signaling pathway.2
367247852023Bi-allelic TTI1 variants cause an autosomal-recessive neurodevelopmental disorder with microcephaly.1
364031972023TTI1 promotes non-small-cell lung cancer progression by regulating the mTOR signaling pathway.2
367247852023Bi-allelic TTI1 variants cause an autosomal-recessive neurodevelopmental disorder with microcephaly.1
348385212022Structure of the Human TELO2-TTI1-TTI2 Complex.6
348385212022Structure of the Human TELO2-TTI1-TTI2 Complex.6
246571682014Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2.72
246571682014Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2.72
204272872010Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.129
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.14
208106502010A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.0
204272872010Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.129
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.14
208106502010A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.0

Citation

Dessen P

TTI1 (TELO2 interacting protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75305/js/img/logo-atlas-4.svg