UBE2K (ubiquitin conjugating enzyme E2 K)

2014-11-01  

Identity

HGNC
LOCATION
4p14
LOCUSID
ALIAS
E2-25K,HIP2,HYPG,LIG,UBC1
FUSION GENES

Other Information

Locus ID:

NCBI: 3093
MIM: 602846
HGNC: 4914
Ensembl: ENSG00000078140

Variants:

dbSNP: 3093
ClinVar: 3093
TCGA: ENSG00000078140
COSMIC: UBE2K

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000078140ENST00000261427P61086
ENSG00000078140ENST00000445950P61086
ENSG00000078140ENST00000503368P61086
ENSG00000078140ENST00000510719D6RFX1
ENSG00000078140ENST00000510934D6RDM7

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Innate Immune SystemREACTOMER-HSA-168249
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
Negative regulators of RIG-I/MDA5 signalingREACTOMER-HSA-936440
Protein ubiquitinationREACTOMER-HSA-8852135
Synthesis of active ubiquitin: roles of E1 and E2 enzymesREACTOMER-HSA-8866652

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
170927422007Ubiquitin-conjugating enzyme E2-25K increases aggregate formation and cell death in polyglutamine diseases.31
168680772006E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system.19
208267782010Structural basis of E2-25K/UBB+1 interaction leading to proteasome inhibition and neurotoxicity.15
265924442015The molecular basis of lysine 48 ubiquitin chain synthesis by Ube2K.10
212815992011The E2-25K ubiquitin-associated (UBA) domain aids in polyubiquitin chain synthesis and linkage specificity.7
297251242018Active Site Gate Dynamics Modulate the Catalytic Activity of the Ubiquitination Enzyme E2-25K.2
303369762018Crystal structure of the Ube2K/E2-25K and K48-linked di-ubiquitin complex provides structural insight into the mechanism of K48-specific ubiquitin chain synthesis.2
309017252019Blood and brain protein levels of ubiquitin-conjugating enzyme E2K (UBE2K) are elevated in individuals with schizophrenia.2
205379842010Hip2 interacts with and destabilizes Smac/DIABLO.1
221647712011Vitexin inhibits polyubiquitin synthesis by the ubiquitin-conjugating enzyme E2-25K.1

Citation

Dessen P

UBE2K (ubiquitin conjugating enzyme E2 K)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75418/ube2k