UCP1 (uncoupling protein 1)

2014-11-01  

Identity

HGNC
UCP1
LOCATION
4q31.1
LOCUSID
7350
ALIAS
SLC25A7,UCP

Other Information

Locus ID:

NCBI: 7350
MIM: 113730
HGNC: 12517
Ensembl: ENSG00000109424

Variants:

dbSNP: 7350
ClinVar: 7350
TCGA: ENSG00000109424
COSMIC: UCP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109424ENST00000262999P25874

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
PPAR signaling pathwayKEGGko03320
Huntington's diseaseKEGGko05016
PPAR signaling pathwayKEGGhsa03320
Huntington's diseaseKEGGhsa05016
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.REACTOMER-HSA-163200
Mitochondrial Uncoupling ProteinsREACTOMER-HSA-166187
The fatty acid cycling modelREACTOMER-HSA-167826
The proton buffering modelREACTOMER-HSA-167827
Apelin signaling pathwayKEGGhsa04371

References

Pubmed IDYearTitleCitations
389174102024UCP1 expression in human brown adipose tissue is inversely associated with cardiometabolic risk factors.0
389174102024UCP1 expression in human brown adipose tissue is inversely associated with cardiometabolic risk factors.0
366517112023Expressions of mRNA and encoded proteins of mitochondrial uncoupling protein genes (UCP1, UCP2, and UCP3) in epicardial and mediastinal adipose tissue and associations with coronary artery disease.2
372569482023Structural basis of purine nucleotide inhibition of human uncoupling protein 1.8
373364862023Structural basis for the binding of DNP and purine nucleotides onto UCP1.8
380690282023Loss of Uncoupling Protein 1 Expression in the Subcutaneous Adipose Tissue Predicts Childhood Obesity.2
366517112023Expressions of mRNA and encoded proteins of mitochondrial uncoupling protein genes (UCP1, UCP2, and UCP3) in epicardial and mediastinal adipose tissue and associations with coronary artery disease.2
372569482023Structural basis of purine nucleotide inhibition of human uncoupling protein 1.8
373364862023Structural basis for the binding of DNP and purine nucleotides onto UCP1.8
380690282023Loss of Uncoupling Protein 1 Expression in the Subcutaneous Adipose Tissue Predicts Childhood Obesity.2
350905032022UCP1 modulates immune infiltration level and survival outcome in ovarian cancer patients.3
355419002022Mitochondrial Protein UCP1 Inhibits the Malignant Behaviors of Triple-negative Breast Cancer through Activation of Mitophagy and Pyroptosis.9
355988462022Inhibition of STAT3 enhances UCP1 expression and mitochondrial function in brown adipocytes.0
356915292022Activating ligands of Uncoupling protein 1 identified by rapid membrane protein thermostability shift analysis.3
358051222022Chronic Fatty Acid Depletion Induces Uncoupling Protein 1 (UCP1) Expression to Coordinate Mitochondrial Inducible Proton Leak in a Human-Brown-Adipocyte Model.3

Citation

Dessen P

UCP1 (uncoupling protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75459/css/favicon/apple-touch-icon.png