KYAT1 (kynurenine aminotransferase 1)

2016-11-01 Affiliation

HGNC

KYAT1

LOCATION

9q34.11

LOCUSID

883

ALIAS

CCBL1,GTK,KAT1,KATI

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

NCBI: 883
MIM: 600547
HGNC: 1564
Ensembl: ENSG00000286112

dbSNP: 883
ClinVar: 883
TCGA: ENSG00000286112
COSMIC: KYAT1

Gene ID	Transcript ID	Uniprot
ENSG00000286112	ENST00000651925	A0A494C066

Pathway	Source	External ID
Tryptophan metabolism	KEGG	ko00380
Selenocompound metabolism	KEGG	ko00450
Tryptophan metabolism	KEGG	hsa00380
Selenocompound metabolism	KEGG	hsa00450
Metabolic pathways	KEGG	hsa01100
Chemical carcinogenesis	KEGG	hsa05204
Chemical carcinogenesis	KEGG	ko05204
Metabolism	REACTOME	R-HSA-1430728
Metabolism of amino acids and derivatives	REACTOME	R-HSA-71291
Amino acid synthesis and interconversion (transamination)	REACTOME	R-HSA-70614
Phenylalanine and tyrosine catabolism	REACTOME	R-HSA-71182
Tryptophan catabolism	REACTOME	R-HSA-71240
Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism	REACTOME	R-HSA-6788656

Pubmed ID	Year	Title	Citations
15016471	2004	The role of glutamine transaminase K (GTK) in sulfur and alpha-keto acid metabolism in the brain, and in the possible bioactivation of neurotoxicants.	39
16828464	2006	Preliminary evidence for a link between schizophrenia and NMDA-glycine site receptor ligand metabolic enzymes, d-amino acid oxidase (DAAO) and kynurenine aminotransferase-1 (KAT-1).	25
18342615	2008	Substrate specificity of human glutamine transaminase K as an aminotransferase and as a cysteine S-conjugate beta-lyase.	23
22093698	2012	New insights into the metabolism of organomercury compounds: mercury-containing cysteine S-conjugates are substrates of human glutamine transaminase K and potent inactivators of cystathionine γ-lyase.	5
31231915	2019	Upregulation of the Glutaminase II Pathway Contributes to Glutamate Production upon Glutaminase 1 Inhibition in Pancreatic Cancer.	4
28706436	2017	The presence of kynurenine aminotransferases in the human cornea: Evidence from bioinformatics analysis of gene expression and immunohistochemical staining.	2

Dessen P

KYAT1 (kynurenine aminotransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-11-01