BID (BH3 interacting domain death agonist)

2003-11-01  

Identity

HGNC
LOCATION
22q11.21
LOCUSID
ALIAS
FP497
FUSION GENES

Other Information

Locus ID:

NCBI: 637
MIM: 601997
HGNC: 1050
Ensembl: ENSG00000015475

Variants:

dbSNP: 637
ClinVar: 637
TCGA: ENSG00000015475
COSMIC: BID

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000015475ENST00000317361P55957
ENSG00000015475ENST00000342111P55957
ENSG00000015475ENST00000399765P55957
ENSG00000015475ENST00000399765B2ZP79
ENSG00000015475ENST00000399767P55957
ENSG00000015475ENST00000399767B2ZP79
ENSG00000015475ENST00000399774P55957
ENSG00000015475ENST00000399774A8ASI8
ENSG00000015475ENST00000551952P55957
ENSG00000015475ENST00000551952A8ASI8
ENSG00000015475ENST00000611040P55957
ENSG00000015475ENST00000611040B2ZP79
ENSG00000015475ENST00000614949P55957
ENSG00000015475ENST00000614949B2ZP79
ENSG00000015475ENST00000615414P55957
ENSG00000015475ENST00000615414B2ZP79
ENSG00000015475ENST00000617586B2ZP78
ENSG00000015475ENST00000622694P55957
ENSG00000015475ENST00000622694A8ASI8

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
p53 signaling pathwayKEGGko04115
ApoptosisKEGGko04210
Natural killer cell mediated cytotoxicityKEGGko04650
Alzheimer's diseaseKEGGko05010
Amyotrophic lateral sclerosis (ALS)KEGGko05014
p53 signaling pathwayKEGGhsa04115
ApoptosisKEGGhsa04210
Natural killer cell mediated cytotoxicityKEGGhsa04650
Alzheimer's diseaseKEGGhsa05010
Amyotrophic lateral sclerosis (ALS)KEGGhsa05014
Pathways in cancerKEGGhsa05200
Viral myocarditisKEGGhsa05416
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Non-alcoholic fatty liver disease (NAFLD)KEGGhsa04932
Non-alcoholic fatty liver disease (NAFLD)KEGGko04932
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Intrinsic Pathway for ApoptosisREACTOMER-HSA-109606
Activation, myristolyation of BID and translocation to mitochondriaREACTOMER-HSA-75108
Activation of BH3-only proteinsREACTOMER-HSA-114452
Activation of BAD and translocation to mitochondriaREACTOMER-HSA-111447
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 membersREACTOMER-HSA-111453
Activation, translocation and oligomerization of BAXREACTOMER-HSA-114294
Activation and oligomerization of BAK proteinREACTOMER-HSA-111452
TP53 Regulates Transcription of Cell Death GenesREACTOMER-HSA-5633008
TP53 Regulates Transcription of Genes Involved in Cytochrome C ReleaseREACTOMER-HSA-6803204
Apoptosis - multiple speciesKEGGko04215
Apoptosis - multiple speciesKEGGhsa04215
Platinum drug resistanceKEGGko01524
Platinum drug resistanceKEGGhsa01524

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
172899992007Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak.474
124192442002Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane.424
172007142007Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.223
170524542006A stapled BID BH3 helix directly binds and activates BAX.152
145814762004Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins.109
184690042008Cysteine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologues.104
155743352004The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA.97
240749542013BID preferentially activates BAK while BIM preferentially activates BAX, affecting chemotherapy response.90
150240762004Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance.89
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85

Citation

Dessen P

BID (BH3 interacting domain death agonist)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/792/bid-(bh3-interacting-domain-death-agonist)