BID (BH3 interacting domain death agonist)

2003-11-01  

Identity

HGNC
BID
LOCATION
22q11.21
LOCUSID
637
ALIAS
FP497
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 637
MIM: 601997
HGNC: 1050
Ensembl: ENSG00000015475

Variants:

dbSNP: 637
ClinVar: 637
TCGA: ENSG00000015475
COSMIC: BID

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000015475ENST00000317361P55957
ENSG00000015475ENST00000342111P55957
ENSG00000015475ENST00000399765P55957
ENSG00000015475ENST00000399765B2ZP79
ENSG00000015475ENST00000399767P55957
ENSG00000015475ENST00000399767B2ZP79
ENSG00000015475ENST00000399774P55957
ENSG00000015475ENST00000399774A8ASI8
ENSG00000015475ENST00000551952P55957
ENSG00000015475ENST00000551952A8ASI8
ENSG00000015475ENST00000611040P55957
ENSG00000015475ENST00000611040B2ZP79
ENSG00000015475ENST00000614949P55957
ENSG00000015475ENST00000614949B2ZP79
ENSG00000015475ENST00000615414P55957
ENSG00000015475ENST00000615414B2ZP79
ENSG00000015475ENST00000617586B2ZP78
ENSG00000015475ENST00000622694P55957
ENSG00000015475ENST00000622694A8ASI8

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
p53 signaling pathwayKEGGko04115
ApoptosisKEGGko04210
Natural killer cell mediated cytotoxicityKEGGko04650
Alzheimer's diseaseKEGGko05010
Amyotrophic lateral sclerosis (ALS)KEGGko05014
p53 signaling pathwayKEGGhsa04115
ApoptosisKEGGhsa04210
Natural killer cell mediated cytotoxicityKEGGhsa04650
Alzheimer's diseaseKEGGhsa05010
Amyotrophic lateral sclerosis (ALS)KEGGhsa05014
Pathways in cancerKEGGhsa05200
Viral myocarditisKEGGhsa05416
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Non-alcoholic fatty liver disease (NAFLD)KEGGhsa04932
Non-alcoholic fatty liver disease (NAFLD)KEGGko04932
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Intrinsic Pathway for ApoptosisREACTOMER-HSA-109606
Activation, myristolyation of BID and translocation to mitochondriaREACTOMER-HSA-75108
Activation of BH3-only proteinsREACTOMER-HSA-114452
Activation of BAD and translocation to mitochondriaREACTOMER-HSA-111447
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 membersREACTOMER-HSA-111453
Activation, translocation and oligomerization of BAXREACTOMER-HSA-114294
Activation and oligomerization of BAK proteinREACTOMER-HSA-111452
TP53 Regulates Transcription of Cell Death GenesREACTOMER-HSA-5633008
TP53 Regulates Transcription of Genes Involved in Cytochrome C ReleaseREACTOMER-HSA-6803204
Apoptosis - multiple speciesKEGGko04215
Apoptosis - multiple speciesKEGGhsa04215
Platinum drug resistanceKEGGko01524
Platinum drug resistanceKEGGhsa01524

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
374431142023BID expression determines the apoptotic fate of cancer cells after abrogation of the spindle assembly checkpoint by AURKB or TTK inhibitors.1
374431142023BID expression determines the apoptotic fate of cancer cells after abrogation of the spindle assembly checkpoint by AURKB or TTK inhibitors.1
349317112022BCL-2-family protein tBID can act as a BAX-like effector of apoptosis.46
349317112022BCL-2-family protein tBID can act as a BAX-like effector of apoptosis.46
343894472021Influence of thyroid hormone in the expression of the marker pro-apoptosis BID, in spite of the predominance of anti-apoptosis activation in intratiroidal lymphocytic infiltration in Hashimoto's thyroiditis.3
343894472021Influence of thyroid hormone in the expression of the marker pro-apoptosis BID, in spite of the predominance of anti-apoptosis activation in intratiroidal lymphocytic infiltration in Hashimoto's thyroiditis.3
306523482019Menadione-induced apoptosis in U937 cells involves Bid cleavage and stefin B degradation.3
317678572019BID and the α-bisabolol-triggered cell death program: converging on mitochondria and lysosomes.11
306523482019Menadione-induced apoptosis in U937 cells involves Bid cleavage and stefin B degradation.3
317678572019BID and the α-bisabolol-triggered cell death program: converging on mitochondria and lysosomes.11
294407082018Differential role of FL-BID and t-BID during verotoxin-1-induced apoptosis in Burkitt's lymphoma cells.12
299697812018MicroRNA-500a Promotes the Progression of Hepatocellular Carcinoma by Post-Transcriptionally Targeting BID.9
302810242018Bid maintains mitochondrial cristae structure and function and protects against cardiac disease in an integrative genomics study.16
294407082018Differential role of FL-BID and t-BID during verotoxin-1-induced apoptosis in Burkitt's lymphoma cells.12
299697812018MicroRNA-500a Promotes the Progression of Hepatocellular Carcinoma by Post-Transcriptionally Targeting BID.9

Citation

Dessen P

BID (BH3 interacting domain death agonist)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/792/gene-fusions-explorer/js/js/web-card-_common.js