INTS11 (integrator complex subunit 11)

2017-09-01  

Identity

HGNC
INTS11
LOCATION
1p36.33
LOCUSID
54973
ALIAS
CPSF3L,CPSF73L,INT11,RC-68,RC68

Other Information

Locus ID:

NCBI: 54973
MIM: 611354
HGNC: 26052
Ensembl: ENSG00000127054

Variants:

dbSNP: 54973
ClinVar: 54973
TCGA: ENSG00000127054
COSMIC: INTS11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127054ENST00000411962C9IYS7
ENSG00000127054ENST00000419704Q5TA45
ENSG00000127054ENST00000419704A0A024R073
ENSG00000127054ENST00000421495J3QRY6
ENSG00000127054ENST00000429572A0A087WXT8
ENSG00000127054ENST00000430786H7C247
ENSG00000127054ENST00000434694C9J979
ENSG00000127054ENST00000435064Q5TA45
ENSG00000127054ENST00000435064A0A024R0F2
ENSG00000127054ENST00000450926Q5TA45
ENSG00000127054ENST00000458452E9PIS0
ENSG00000127054ENST00000470679H0YE15
ENSG00000127054ENST00000498476E9PQF0
ENSG00000127054ENST00000525285H0YEQ9
ENSG00000127054ENST00000526332E9PNH9
ENSG00000127054ENST00000526797E9PKA4
ENSG00000127054ENST00000527098E9PIX9
ENSG00000127054ENST00000527383H0YCE0
ENSG00000127054ENST00000527719E9PI75
ENSG00000127054ENST00000528879E9PNS4
ENSG00000127054ENST00000530031E9PIG1
ENSG00000127054ENST00000531019E9PJG0
ENSG00000127054ENST00000531377H0YDB1
ENSG00000127054ENST00000532772E9PMA2
ENSG00000127054ENST00000534345E9PIL7
ENSG00000127054ENST00000540437Q5TA45
ENSG00000127054ENST00000545578Q5TA45
ENSG00000127054ENST00000618806Q96HV7
ENSG00000127054ENST00000620829A0A087WYI0

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
RNA polymerase II transcribes snRNA genesREACTOMER-HSA-6807505

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
368223272023An examination of the metal ion content in the active sites of human endonucleases CPSF73 and INTS11.2
379805602023A homozygous variant in INTS11 links mitosis and neurogenesis defects to a severe neurodevelopmental disorder.0
368223272023An examination of the metal ion content in the active sites of human endonucleases CPSF73 and INTS11.2
379805602023A homozygous variant in INTS11 links mitosis and neurogenesis defects to a severe neurodevelopmental disorder.0
345517762021NACK and INTEGRATOR act coordinately to activate Notch-mediated transcription in tumorigenesis.5
345517762021NACK and INTEGRATOR act coordinately to activate Notch-mediated transcription in tumorigenesis.5
294713652018Integrator subunit 4 is a 'Symplekin-like' scaffold that associates with INTS9/11 to form the Integrator cleavage module.43
294713652018Integrator subunit 4 is a 'Symplekin-like' scaffold that associates with INTS9/11 to form the Integrator cleavage module.43
283964332017Molecular basis for the interaction between Integrator subunits IntS9 and IntS11 and its functional importance.40
283964332017Molecular basis for the interaction between Integrator subunits IntS9 and IntS11 and its functional importance.40
222523202012snRNA 3' end formation requires heterodimeric association of integrator subunits.43
222523202012snRNA 3' end formation requires heterodimeric association of integrator subunits.43
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105

Citation

Dessen P

INTS11 (integrator complex subunit 11)

Atlas Genet Cytogenet Oncol Haematol. 2017-09-01

Online version: http://atlasgeneticsoncology.org/gene/79300/favicon/favicon/js/lib/popper.js