BNIP2 (BCL2 interacting protein 2)

2003-11-01 Affiliation

Identity

HGNC

BNIP2

LOCATION

15q22.2

LOCUSID

663

ALIAS

BNIP-2,NIP2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 663
MIM: 603292
HGNC: 1083
Ensembl: ENSG00000140299

Variants:

dbSNP: 663
ClinVar: 663
TCGA: ENSG00000140299
COSMIC: BNIP2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000140299	ENST00000267859	J3KN59
ENSG00000140299	ENST00000415213	Q12982
ENSG00000140299	ENST00000439052	H7C096
ENSG00000140299	ENST00000448414	H7C142
ENSG00000140299	ENST00000607373	Q12982
ENSG00000140299	ENST00000612191	J3KN59

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Developmental Biology	REACTOME	R-HSA-1266738
Myogenesis	REACTOME	R-HSA-525793
CDO in myogenesis	REACTOME	R-HSA-375170

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
35975420	2022	BNIP-2 Activation of Cellular Contractility Inactivates YAP for H9c2 Cardiomyoblast Differentiation.	4
35975420	2022	BNIP-2 Activation of Cellular Contractility Inactivates YAP for H9c2 Cardiomyoblast Differentiation.	4
32789168	2020	BNIP-2 retards breast cancer cell migration by coupling microtubule-mediated GEF-H1 and RhoA activation.	13
32789168	2020	BNIP-2 retards breast cancer cell migration by coupling microtubule-mediated GEF-H1 and RhoA activation.	13
25378581	2015	KIF5B transports BNIP-2 to regulate p38 mitogen-activated protein kinase activation and myoblast differentiation.	7
25472445	2015	BNIP-2 binds phosphatidylserine, localizes to vesicles, and is transported by kinesin-1.	1
25378581	2015	KIF5B transports BNIP-2 to regulate p38 mitogen-activated protein kinase activation and myoblast differentiation.	7
25472445	2015	BNIP-2 binds phosphatidylserine, localizes to vesicles, and is transported by kinesin-1.	1
21130087	2011	SIRT1 deficiency attenuates MPP+-induced apoptosis in dopaminergic cells.	10
21130087	2011	SIRT1 deficiency attenuates MPP+-induced apoptosis in dopaminergic cells.	10
20677014	2010	An approach based on a genome-wide association study reveals candidate loci for narcolepsy.	19
20704564	2010	Identification of the BCL2/adenovirus E1B-19K protein-interacting protein 2 (BNIP-2) as a granzyme B target during human natural killer cell-mediated killing.	4
20855536	2010	Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma.	22
20677014	2010	An approach based on a genome-wide association study reveals candidate loci for narcolepsy.	19
20704564	2010	Identification of the BCL2/adenovirus E1B-19K protein-interacting protein 2 (BNIP-2) as a granzyme B target during human natural killer cell-mediated killing.	4

Citation

Dessen P

BNIP2 (BCL2 interacting protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/821/cancer-prone-explorer/img/logo-atlas-4.svg