BRD1 (bromodomain containing 1)

2003-02-01  

Identity

HGNC
BRD1
LOCATION
22q13.33
LOCUSID
23774
ALIAS
BRL,BRPF1,BRPF2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23774
MIM: 604589
HGNC: 1102
Ensembl: ENSG00000100425

Variants:

dbSNP: 23774
ClinVar: 23774
TCGA: ENSG00000100425
COSMIC: BRD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100425ENST00000216267O95696
ENSG00000100425ENST00000216267A0A024R4W4
ENSG00000100425ENST00000404034O95696
ENSG00000100425ENST00000404034A0A024R4W4
ENSG00000100425ENST00000404760O95696
ENSG00000100425ENST00000404760A0A024R4V5
ENSG00000100425ENST00000438393J3KQ61
ENSG00000100425ENST00000457780O95696
ENSG00000100425ENST00000457780A0A024R4V5

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HATs acetylate histonesREACTOMER-HSA-3214847
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through AcetylationREACTOMER-HSA-6804758

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
218807312011Recognition of unmodified histone H3 by the first PHD finger of bromodomain-PHD finger protein 2 provides insights into the regulation of histone acetyltransferases monocytic leukemic zinc-finger protein (MOZ) and MOZ-related factor (MORF).31
228203062012Solution structure of an atypical PHD finger in BRPF2 and its interaction with DNA.24
196938002010Support of association between BRD1 and both schizophrenia and bipolar affective disorder.17
196938002010Support of association between BRD1 and both schizophrenia and bipolar affective disorder.17
271420602016Identification of the BRD1 interaction network and its impact on mental disorder risk.9
197636152009Further immunohistochemical characterization of BRD1 a new susceptibility gene for schizophrenia and bipolar affective disorder.6
280954952017DNA Methylation Analysis of BRD1 Promoter Regions and the Schizophrenia rs138880 Risk Allele.4
284310652017CHA2DS2-VASc score and blood biomarkers to identify patients with atrial high-rate episodes and paroxysmal atrial fibrillation.4
199082362010Association study of bromodomain-containing 1 gene with schizophrenia in Japanese population.3

Citation

Dessen P

BRD1 (bromodomain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/835/brd1-(bromodomain-containing-1)