SSX1 (SSX family member 1)

2003-02-01  

Identity

HGNC
LOCATION
Xp11.23
LOCUSID
ALIAS
CT5.1,SSRC
FUSION GENES

Other Information

Locus ID:

NCBI: 6756
MIM: 312820
HGNC: 11335
Ensembl: ENSG00000126752

Variants:

dbSNP: 6756
ClinVar: 6756
TCGA: ENSG00000126752
COSMIC: SSX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000126752ENST00000376919Q16384

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
235406912013Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcoma.116
192047262009Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.63
241664952014SS18-SSX fusion protein-induced Wnt/β-catenin signaling is a therapeutic target in synovial sarcoma.28
162474612006IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SSX1.21
295029552018The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma.20
161526172006Gene expression profiles relate to SS18/SSX fusion type in synovial sarcoma.18
199362582009Epigenetic features of human mesenchymal stem cells determine their permissiveness for induction of relevant transcriptional changes by SYT-SSX1.16
126960682003A novel fusion gene, SS18L1/SSX1, in synovial sarcoma.14
201983252010Downregulation of SS18-SSX1 expression in synovial sarcoma by small interfering RNA enhances the focal adhesion pathway and inhibits anchorage-independent growth in vitro and tumor growth in vivo.14
237161142014Loss of SS18-SSX1 inhibits viability and induces apoptosis in synovial sarcoma.11

Citation

Dessen P

SSX1 (SSX family member 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/87/ssx1