NOD1 (nucleotide binding oligomerization domain containing 1)

2003-08-01 Affiliation

Identity

HGNC

NOD1

LOCATION

7p14.3

LOCUSID

10392

ALIAS

CARD4,CLR7.1,NLRC1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10392
MIM: 605980
HGNC: 16390
Ensembl: ENSG00000106100

Variants:

dbSNP: 10392
ClinVar: 10392
TCGA: ENSG00000106100
COSMIC: NOD1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000106100	ENST00000222823	Q9Y239
ENSG00000106100	ENST00000222823	A0A024RA73
ENSG00000106100	ENST00000411552	A0A1B0GX71
ENSG00000106100	ENST00000413433	A0A1B0GX71
ENSG00000106100	ENST00000419601	C9J8X8
ENSG00000106100	ENST00000419799	A0A1B0GX71
ENSG00000106100	ENST00000434755	G3XAL1

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Epithelial cell signaling in Helicobacter pylori infection	KEGG	ko05120
Epithelial cell signaling in Helicobacter pylori infection	KEGG	hsa05120
Shigellosis	KEGG	hsa05131
NOD-like receptor signaling pathway	KEGG	ko04621
NOD-like receptor signaling pathway	KEGG	hsa04621
Pertussis	KEGG	ko05133
Pertussis	KEGG	hsa05133
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Toll-Like Receptors Cascades	REACTOME	R-HSA-168898
Toll Like Receptor 10 (TLR10) Cascade	REACTOME	R-HSA-168142
MyD88 cascade initiated on plasma membrane	REACTOME	R-HSA-975871
TAK1 activates NFkB by phosphorylation and activation of IKKs complex	REACTOME	R-HSA-445989
MAP kinase activation in TLR cascade	REACTOME	R-HSA-450294
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	REACTOME	R-HSA-450321
activated TAK1 mediates p38 MAPK activation	REACTOME	R-HSA-450302
Toll Like Receptor 3 (TLR3) Cascade	REACTOME	R-HSA-168164
MyD88-independent TLR3/TLR4 cascade	REACTOME	R-HSA-166166
TRIF-mediated TLR3/TLR4 signaling	REACTOME	R-HSA-937061
Toll Like Receptor 5 (TLR5) Cascade	REACTOME	R-HSA-168176
Toll Like Receptor 7/8 (TLR7/8) Cascade	REACTOME	R-HSA-168181
MyD88 dependent cascade initiated on endosome	REACTOME	R-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	REACTOME	R-HSA-975138
Toll Like Receptor 9 (TLR9) Cascade	REACTOME	R-HSA-168138
Toll Like Receptor 4 (TLR4) Cascade	REACTOME	R-HSA-166016
Activated TLR4 signalling	REACTOME	R-HSA-166054
MyD88:Mal cascade initiated on plasma membrane	REACTOME	R-HSA-166058
Toll Like Receptor 2 (TLR2) Cascade	REACTOME	R-HSA-181438
Toll Like Receptor TLR1:TLR2 Cascade	REACTOME	R-HSA-168179
Toll Like Receptor TLR6:TLR2 Cascade	REACTOME	R-HSA-168188
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	REACTOME	R-HSA-168643
NOD1/2 Signaling Pathway	REACTOME	R-HSA-168638
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-1 signaling	REACTOME	R-HSA-446652
Deubiquitination	REACTOME	R-HSA-5688426
Ovarian tumor domain proteases	REACTOME	R-HSA-5689896

References

Pubmed ID	Year	Title	Citations
19898471	2010	Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry.	463
12791997	2003	Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan.	414
16493424	2006	Signalling pathways and molecular interactions of NOD1 and NOD2.	242
19120480	2009	Function of Nod-like receptors in microbial recognition and host defense.	215
12871942	2003	Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2.	193
27007849	2016	NOD1 and NOD2 signalling links ER stress with inflammation.	126
19667203	2009	XIAP mediates NOD signaling via interaction with RIP2.	109
16260731	2005	IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism.	97
17403538	2007	Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines.	97
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85

Citation

Dessen P

NOD1 (nucleotide binding oligomerization domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/912/nod1-(nucleotide-binding-oligomerization-domain-containing-1)