CASP2 (caspase 2)

2003-02-01  

Identity

HGNC
LOCATION
7q34
LOCUSID
ALIAS
CASP-2,ICH1,NEDD-2,NEDD2,PPP1R57
FUSION GENES

Other Information

Locus ID:

NCBI: 835
MIM: 600639
HGNC: 1503
Ensembl: ENSG00000106144

Variants:

dbSNP: 835
ClinVar: 835
TCGA: ENSG00000106144
COSMIC: CASP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106144ENST00000310447P42575
ENSG00000106144ENST00000310447A0A0S2Z3H1
ENSG00000106144ENST00000350623A0A087WYM1
ENSG00000106144ENST00000392925C9JRR9
ENSG00000106144ENST00000619992A0A087WYM1

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
ApoptosisKEGGko04210
ApoptosisKEGGhsa04210
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathwaysREACTOMER-HSA-168643
NOD1/2 Signaling PathwayREACTOMER-HSA-168638
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
Cell death signalling via NRAGE, NRIF and NADEREACTOMER-HSA-204998
NADE modulates death signallingREACTOMER-HSA-205025
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Transcription of Cell Death GenesREACTOMER-HSA-5633008
TP53 Regulates Transcription of Caspase Activators and CaspasesREACTOMER-HSA-6803207

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
230422942012IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.208
150733212004The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress.198
121937892002Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization.147
118324782002Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria.117
120655942002Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis.97
152978852004The biochemical mechanism of caspase-2 activation.67
171599002007Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway.64
217268102011Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop.52
188406862008Up-regulation of the proapoptotic caspase 2 splicing isoform by a candidate tumor suppressor, RBM5.46
197304122009Restraint of apoptosis during mitosis through interdomain phosphorylation of caspase-2.45

Citation

Dessen P

CASP2 (caspase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/919/casp2-(caspase-2)