CAT (catalase)

2003-08-01  

Identity

HGNC
LOCATION
11p13
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 847
MIM: 115500
HGNC: 1516
Ensembl: ENSG00000121691

Variants:

dbSNP: 847
ClinVar: 847
TCGA: ENSG00000121691
COSMIC: CAT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000121691ENST00000241052P04040
ENSG00000121691ENST00000241052A0A384P5Q0
ENSG00000121691ENST00000650153A0A3B3ITJ0

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Tryptophan metabolismKEGGko00380
Glyoxylate and dicarboxylate metabolismKEGGko00630
Amyotrophic lateral sclerosis (ALS)KEGGko05014
Tryptophan metabolismKEGGhsa00380
Glyoxylate and dicarboxylate metabolismKEGGhsa00630
Amyotrophic lateral sclerosis (ALS)KEGGhsa05014
PeroxisomeKEGGko04146
PeroxisomeKEGGhsa04146
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
FoxO signaling pathwayKEGGhsa04068
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Purine metabolismREACTOMER-HSA-73847
Purine catabolismREACTOMER-HSA-74259
Cellular responses to stressREACTOMER-HSA-2262752
Detoxification of Reactive Oxygen SpeciesREACTOMER-HSA-3299685
Longevity regulating pathwayKEGGhsa04211
Longevity regulating pathway - multiple speciesKEGGko04213
Longevity regulating pathway - multiple speciesKEGGhsa04213
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA130620651anthracyclines and related substancesChemicalClinicalAnnotationassociatedPD19863340
PA443309AlcoholismDiseaseClinicalAnnotationassociated25514903
PA446155Precursor Cell Lymphoblastic Leukemia-LymphomaDiseaseClinicalAnnotationassociatedPD19863340
PA448073ethanolChemicalClinicalAnnotationassociated25514903

References

Pubmed IDYearTitleCitations
211091992010Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance.137
198745742009Genetical genomic determinants of alcohol consumption in rats and humans.93
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
163854462006A testing framework for identifying susceptibility genes in the presence of epistasis.81
189308112008Severe oxidative damage in multiple sclerosis lesions coincides with enhanced antioxidant enzyme expression.77
184858952008Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression.73
211313942011TGF-β regulates Nox4, MnSOD and catalase expression, and IL-6 release in airway smooth muscle cells.65
127302222003UVB light stimulates production of reactive oxygen species: unexpected role for catalase.62
170055952006Age-dependent changes in the expression of superoxide dismutases and catalase are associated with ultrastructural modifications in human granulosa cells.49
164670732006Functional variants of antioxidant genes in smokers with COPD and in those with normal lung function.48

Citation

Dessen P

CAT (catalase)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/929/cat