CAT (catalase)

2003-08-01  

Identity

HGNC
CAT
LOCATION
11p13
LOCUSID
847
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 847
MIM: 115500
HGNC: 1516
Ensembl: ENSG00000121691

Variants:

dbSNP: 847
ClinVar: 847
TCGA: ENSG00000121691
COSMIC: CAT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000121691ENST00000241052P04040
ENSG00000121691ENST00000241052A0A384P5Q0
ENSG00000121691ENST00000650153A0A3B3ITJ0

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Tryptophan metabolismKEGGko00380
Glyoxylate and dicarboxylate metabolismKEGGko00630
Amyotrophic lateral sclerosis (ALS)KEGGko05014
Tryptophan metabolismKEGGhsa00380
Glyoxylate and dicarboxylate metabolismKEGGhsa00630
Amyotrophic lateral sclerosis (ALS)KEGGhsa05014
PeroxisomeKEGGko04146
PeroxisomeKEGGhsa04146
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
FoxO signaling pathwayKEGGhsa04068
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Purine metabolismREACTOMER-HSA-73847
Purine catabolismREACTOMER-HSA-74259
Cellular responses to stressREACTOMER-HSA-2262752
Detoxification of Reactive Oxygen SpeciesREACTOMER-HSA-3299685
Longevity regulating pathwayKEGGhsa04211
Longevity regulating pathway - multiple speciesKEGGko04213
Longevity regulating pathway - multiple speciesKEGGhsa04213
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA130620651anthracyclines and related substancesChemicalClinicalAnnotationassociatedPD19863340
PA443309AlcoholismDiseaseClinicalAnnotationassociated25514903
PA446155Precursor Cell Lymphoblastic Leukemia-LymphomaDiseaseClinicalAnnotationassociatedPD19863340
PA448073ethanolChemicalClinicalAnnotationassociated25514903

References

Pubmed IDYearTitleCitations
382857822024Superoxide Dismutase (rs2070424, rs4880, rs2536512) and Catalase (rs794316, rs1001179) SNPs and their Association with Breast Cancer Risk: Findings from a Hospital Based Case-Control Study.0
384241812024Parkin inhibits proliferation and migration of bladder cancer via ubiquitinating Catalase.0
382857822024Superoxide Dismutase (rs2070424, rs4880, rs2536512) and Catalase (rs794316, rs1001179) SNPs and their Association with Breast Cancer Risk: Findings from a Hospital Based Case-Control Study.0
384241812024Parkin inhibits proliferation and migration of bladder cancer via ubiquitinating Catalase.0
359642332023Association of Catalase Gene Polymorphisms with Idiopathic Nephrotic Syndrome in a Chinese Pediatric Population.1
365214062023Catalase and interleukin-6 serum elevation in a prediction of treatment-resistance in male schizophrenia patients.2
369014072023Intensity of Depression Symptoms Is Negatively Associated with Catalase Activity in Master Athletes.0
371096662023Evaluation of CAT Variants A-89T, C389T, and C419T in Patients with Vitiligo in the Saudi Population.1
374056012023Variation of the genes encoding antioxidant enzymes SOD2 (rs4880), GPX1 (rs1050450), and CAT (rs1001179) and susceptibility to male infertility: a genetic association study and in silico analysis.1
376700442023Differences in catalase levels between malaria-infected individuals and uninfected controls: a systematic review and meta-analysis.1
377594512023Non-Alcoholic Fatty Liver Disease Is Associated with a Decreased Catalase (CAT) Level, CT Genotypes and the T Allele of the -262 C/T CAT Polymorphism.1
359642332023Association of Catalase Gene Polymorphisms with Idiopathic Nephrotic Syndrome in a Chinese Pediatric Population.1
365214062023Catalase and interleukin-6 serum elevation in a prediction of treatment-resistance in male schizophrenia patients.2
369014072023Intensity of Depression Symptoms Is Negatively Associated with Catalase Activity in Master Athletes.0
371096662023Evaluation of CAT Variants A-89T, C389T, and C419T in Patients with Vitiligo in the Saudi Population.1

Citation

Dessen P

CAT (catalase)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/929/gene-fusions-explorer/case-report-explorer/js/lib/jquery-3.5.1.min.js