CBFA2T2 (CBFA2/RUNX1 partner transcriptional co-repressor 2)

2003-02-01  

Identity

HGNC
CBFA2T2
LOCATION
20q11.22
LOCUSID
9139
ALIAS
EHT,MTGR1,ZMYND3,p85
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9139
MIM: 603672
HGNC: 1536
Ensembl: ENSG00000078699

Variants:

dbSNP: 9139
ClinVar: 9139
TCGA: ENSG00000078699
COSMIC: CBFA2T2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000078699ENST00000342704O43439
ENSG00000078699ENST00000344201O43439
ENSG00000078699ENST00000346541O43439
ENSG00000078699ENST00000359606O43439
ENSG00000078699ENST00000375279O43439
ENSG00000078699ENST00000397800O43439
ENSG00000078699ENST00000492345O43439
ENSG00000078699ENST00000543126Q68DC6

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
327034012020CBFA2T2 promotes adipogenic differentiation of mesenchymal stem cells by regulating CEBPA.5
327034012020CBFA2T2 promotes adipogenic differentiation of mesenchymal stem cells by regulating CEBPA.5
272704372016Myeloid translocation genes differentially regulate colorectal cancer programs.8
272812182016Co-repressor CBFA2T2 regulates pluripotency and germline development.28
272704372016Myeloid translocation genes differentially regulate colorectal cancer programs.8
272812182016Co-repressor CBFA2T2 regulates pluripotency and germline development.28
224431752012The leukemia associated nuclear corepressor ETO homologue genes MTG16 and MTGR1 are regulated differently in hematopoietic cells.5
224431752012The leukemia associated nuclear corepressor ETO homologue genes MTG16 and MTGR1 are regulated differently in hematopoietic cells.5
205206372010CBFA2T2 and C20orf112: two novel fusion partners of RUNX1 in acute myeloid leukemia.16
205206372010CBFA2T2 and C20orf112: two novel fusion partners of RUNX1 in acute myeloid leukemia.16
190266872009Loss of function genetic screens reveal MTGR1 as an intracellular repressor of beta1 integrin-dependent neurite outgrowth.2
190266872009Loss of function genetic screens reveal MTGR1 as an intracellular repressor of beta1 integrin-dependent neurite outgrowth.2
185861232008Transcriptional repression by leukaemia-associated ETO family members can be independent of oligomerization and coexpressed hSIN3B and N-CoR.3
185861232008Transcriptional repression by leukaemia-associated ETO family members can be independent of oligomerization and coexpressed hSIN3B and N-CoR.3

Citation

Dessen P

CBFA2T2 (CBFA2/RUNX1 partner transcriptional co-repressor 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/934/cancer-prone-explorer/haematological-explorer/css/template-card.css