CCL4 (C-C motif chemokine ligand 4)

2003-08-01  

Identity

HGNC
CCL4
LOCATION
17q12
LOCUSID
6351
ALIAS
ACT2,AT744.1,G-26,HC21,LAG-1,LAG1,MIP-1-beta,MIP1B,MIP1B1,SCYA2,SCYA4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6351
MIM: 182284
HGNC: 10630
Ensembl: ENSG00000275302

Variants:

dbSNP: 6351
ClinVar: 6351
TCGA: ENSG00000275302
COSMIC: CCL4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000275302ENST00000615863P13236
ENSG00000275302ENST00000621626Q7M4M2

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Toll-like receptor signaling pathwayKEGGko04620
Cytokine-cytokine receptor interactionKEGGhsa04060
Toll-like receptor signaling pathwayKEGGhsa04620
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Cytosolic DNA-sensing pathwayKEGGko04623
Cytosolic DNA-sensing pathwayKEGGhsa04623
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-10 signalingREACTOMER-HSA-6783783

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
389532142024The causal relationship between immune cells mediating FIT3L, CCL4, OSM, and skin-derived deteriorated tumors.1
389532142024The causal relationship between immune cells mediating FIT3L, CCL4, OSM, and skin-derived deteriorated tumors.1
370674012023m7G-related genes-NCBP2 and EIF4E3 determine immune contexture in head and neck squamous cell carcinoma by regulating CCL4/CCL5 expression.7
370674012023m7G-related genes-NCBP2 and EIF4E3 determine immune contexture in head and neck squamous cell carcinoma by regulating CCL4/CCL5 expression.7
349154822022STAT3 Promotes Cell Proliferation by Potentiating the CCL4 Transcriptional Activity in Diffuse Large B-Cell Lymphoma.2
359642692022Expression and potential role of CCL4 in CD8+T cells in NSCLC.2
349154822022STAT3 Promotes Cell Proliferation by Potentiating the CCL4 Transcriptional Activity in Diffuse Large B-Cell Lymphoma.2
359642692022Expression and potential role of CCL4 in CD8+T cells in NSCLC.2
325023102021Intratumoral γδ T-Cell Infiltrates, Chemokine (C-C Motif) Ligand 4/Chemokine (C-C Motif) Ligand 5 Protein Expression and Survival in Patients With Hepatocellular Carcinoma.31
333618242021Hypertension delays viral clearance and exacerbates airway hyperinflammation in patients with COVID-19.98
336307632021Beryllium-specific CD4+ T cells induced by chemokine neoantigens perpetuate inflammation.7
344974362021Association of gene and protein expression and genetic polymorphism of CC chemokine ligand 4 in colorectal cancer.5
325023102021Intratumoral γδ T-Cell Infiltrates, Chemokine (C-C Motif) Ligand 4/Chemokine (C-C Motif) Ligand 5 Protein Expression and Survival in Patients With Hepatocellular Carcinoma.31
333618242021Hypertension delays viral clearance and exacerbates airway hyperinflammation in patients with COVID-19.98
336307632021Beryllium-specific CD4+ T cells induced by chemokine neoantigens perpetuate inflammation.7

Citation

Dessen P

CCL4 (C-C motif chemokine ligand 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/945/gene-fusions-explorer/css/img/logo-atlas-4.svg