CCL8 (C-C motif chemokine ligand 8)

2003-06-01  

Identity

HGNC
CCL8
LOCATION
17q12
LOCUSID
6355
ALIAS
HC14,MCP-2,MCP2,SCYA10,SCYA8
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6355
MIM: 602283
HGNC: 10635
Ensembl: ENSG00000108700

Variants:

dbSNP: 6355
ClinVar: 6355
TCGA: ENSG00000108700
COSMIC: CCL8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108700ENST00000394620P80075

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062

References

Pubmed IDYearTitleCitations
366285602023CCL2, CCL8, CXCL12 chemokines in resectable non-small cell lung cancer (NSCLC).1
366285602023CCL2, CCL8, CXCL12 chemokines in resectable non-small cell lung cancer (NSCLC).1
360725822022CCL8 as a promising prognostic factor in diffuse large B-cell lymphoma via M2 macrophage interactions: A bioinformatic analysis of the tumor microenvironment.7
360725822022CCL8 as a promising prognostic factor in diffuse large B-cell lymphoma via M2 macrophage interactions: A bioinformatic analysis of the tumor microenvironment.7
347253212021PERK signaling through C/EBPδ contributes to ER stress-induced expression of immunomodulatory and tumor promoting chemokines by cancer cells.12
347253212021PERK signaling through C/EBPδ contributes to ER stress-induced expression of immunomodulatory and tumor promoting chemokines by cancer cells.12
312256582020Weighted gene correlation network analysis identifies RSAD2, HERC5, and CCL8 as prognostic candidates for breast cancer.27
317486822020CCL8 secreted by tumor-associated macrophages promotes invasion and stemness of glioblastoma cells via ERK1/2 signaling.77
318942812020CCL18 promotes the invasion and metastasis of breast cancer through Annexin A2.23
324325002020Silencing CCL8 inhibited the proliferation and migration of PDGF-BB-stimulated human aortic smooth muscle cells.1
327689612020Possible involvement of crosstalk between endometrial cells and mast cells in the development of endometriosis via CCL8/CCR1.17
312256582020Weighted gene correlation network analysis identifies RSAD2, HERC5, and CCL8 as prognostic candidates for breast cancer.27
317486822020CCL8 secreted by tumor-associated macrophages promotes invasion and stemness of glioblastoma cells via ERK1/2 signaling.77
318942812020CCL18 promotes the invasion and metastasis of breast cancer through Annexin A2.23
324325002020Silencing CCL8 inhibited the proliferation and migration of PDGF-BB-stimulated human aortic smooth muscle cells.1

Citation

Dessen P

CCL8 (C-C motif chemokine ligand 8)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/947/js/template.js