LCP1 (lymphocyte cytosolic protein1)

1998-03-01   Sylvie Galiègue-Zouitina 

U.124 INSERM, I.R.C.L., Place de Verdun, 59045 LILLE Cedex, France

Identity

HGNC
LOCATION
13q14.13
LOCUSID
ALIAS
CP64,HEL-S-37,L-PLASTIN,LC64P,LPL,PLS2
FUSION GENES

DNA/RNA

Description

spans on a 90 kb genomic fragment; 16 exons, large first intron (20kb)

Transcription

3.7 kb mRNA; coding sequence from exon 2 to exon 16: 3500 bp

Proteins

Description

570 amino acids

Expression

restricted to the hematopoietic cells (leukocytes); expression induced in all tumor cells of all tissues

Localisation

membrane

Homology

belongs to an actin-binding protein family (T-Plastin, Fimbrin, I-Plastin)

Implicated in

Entity name
Disease
non Hodgkin follicular as well as Burkitt lymphomas
Cytogenetics
t(3;13) is observed as a secondary anomaly
Hybrid gene
both 5 L-Plastin- 3 BCL6 and 5 BCL6 - 3 L-Plastin, leading to two fusion transcripts
Fusion protein
no fusion protein, but promoter exchange between both partner genes

Bibliography

Pubmed IDLast YearTitleAuthors
96668071998Cytogenetics in multiple myeloma: a multicenter study of 24 patients with t(11;14)(q13;q32) or its variant.Laï JL et al
32111251988Molecular cloning and characterization of plastin, a human leukocyte protein expressed in transformed human fibroblasts.Lin CS et al
84289521993Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells.Lin CS et al
81372921994Activation of the leukocyte plastin gene occurs in most human cancer cells.Park T et al
90175971997Interaction of a Dictyostelium member of the plastin/fimbrin family with actin filaments and actin-myosin complexes.Prassler J et al

Other Information

Locus ID:

NCBI: 3936
MIM: 153430
HGNC: 6528
Ensembl: ENSG00000136167

Variants:

dbSNP: 3936
ClinVar: 3936
TCGA: ENSG00000136167
COSMIC: LCP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136167ENST00000323076P13796
ENSG00000136167ENST00000323076A0A024RDT4
ENSG00000136167ENST00000398576P13796
ENSG00000136167ENST00000398576A0A024RDT4
ENSG00000136167ENST00000416500Q5TBN3
ENSG00000136167ENST00000442275Q5TBN5

Expression (GTEx)

0
500
1000
1500

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
129636942003Plasmin activates the lymphangiogenic growth factors VEGF-C and VEGF-D.53
166360792006Phosphorylation on Ser5 increases the F-actin-binding activity of L-plastin and promotes its targeting to sites of actin assembly in cells.44
162870742006The leukocyte protein L-plastin induces proliferation, invasion and loss of E-cadherin expression in colon cancer cells.31
206838992010Sustained LFA-1 cluster formation in the immune synapse requires the combined activities of L-plastin and calmodulin.31
172944032007Costimulation induced phosphorylation of L-plastin facilitates surface transport of the T cell activation molecules CD69 and CD25.30
225818622012L-plastin regulates polarization and migration in chemokine-stimulated human T lymphocytes.30
232130742013Association between liver-specific gene polymorphisms and their expression levels with nonalcoholic fatty liver disease.25
172903932007Phosphorylation of ectopically expressed L-plastin enhances invasiveness of human melanoma cells.21
201691552010Quantitative kinetic study of the actin-bundling protein L-plastin and of its impact on actin turn-over.17
215253902011Priming of eosinophils by GM-CSF is mediated by protein kinase CbetaII-phosphorylated L-plastin.17

Citation

Sylvie Galiègue-Zouitina

LCP1 (lymphocyte cytosolic protein1)

Atlas Genet Cytogenet Oncol Haematol. 1998-03-01

Online version: http://atlasgeneticsoncology.org/gene/95/lcp1