CCNK (cyclin K)

2003-11-01 Affiliation

Identity

HGNC

CCNK

LOCATION

14q32.2

LOCUSID

8812

ALIAS

CPR4,IDDHDF

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8812
MIM: 603544
HGNC: 1596
Ensembl: ENSG00000090061

Variants:

dbSNP: 8812
ClinVar: 8812
TCGA: ENSG00000090061
COSMIC: CCNK

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000090061	ENST00000389879	O75909
ENSG00000090061	ENST00000389879	A0A024R6K1
ENSG00000090061	ENST00000555049	G3V5E1
ENSG00000090061	ENST00000555842	G3V235
ENSG00000090061	ENST00000557441	G3V2Q3

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Disease	REACTOME	R-HSA-1643685
Infectious disease	REACTOME	R-HSA-5663205
HIV Infection	REACTOME	R-HSA-162906
HIV Life Cycle	REACTOME	R-HSA-162587
Late Phase of HIV Life Cycle	REACTOME	R-HSA-162599
Transcription of the HIV genome	REACTOME	R-HSA-167172
HIV elongation arrest and recovery	REACTOME	R-HSA-167287
Formation of HIV elongation complex in the absence of HIV Tat	REACTOME	R-HSA-167152
Pausing and recovery of HIV elongation	REACTOME	R-HSA-167290
Signal Transduction	REACTOME	R-HSA-162582
Signaling by TGF-beta Receptor Complex	REACTOME	R-HSA-170834
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	REACTOME	R-HSA-2173793
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	REACTOME	R-HSA-2173796
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Transcriptional Regulation by TP53	REACTOME	R-HSA-3700989
RNA Polymerase II Transcription	REACTOME	R-HSA-73857
RNA Polymerase II Pre-transcription Events	REACTOME	R-HSA-674695
RNA Polymerase II Transcription Elongation	REACTOME	R-HSA-75955
Formation of RNA Pol II elongation complex	REACTOME	R-HSA-112382
TP53 Regulates Transcription of DNA Repair Genes	REACTOME	R-HSA-6796648
RNA polymerase II transcribes snRNA genes	REACTOME	R-HSA-6807505

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD
PA128406956	fluorouracil	Chemical	ClinicalAnnotation	associated	PD
PA443560	Breast Neoplasms	Disease	ClinicalAnnotation	associated	PD
PA445113	Neutropenia	Disease	ClinicalAnnotation	associated	PD
PA449165	cyclophosphamide	Chemical	ClinicalAnnotation	associated	PD
PA449476	epirubicin	Chemical	ClinicalAnnotation	associated	PD

References

Pubmed ID	Year	Title	Citations
37597256	2023	CCNK Gene Deficiency Influences Neural Progenitor Cells Via Wnt5a Signaling in CCNK-Related Syndrome.	0
37597256	2023	CCNK Gene Deficiency Influences Neural Progenitor Cells Via Wnt5a Signaling in CCNK-Related Syndrome.	0
36129942	2022	CYCLIN K down-regulation induces androgen receptor gene intronic polyadenylation, variant expression and PARP inhibitor vulnerability in castration-resistant prostate cancer.	6
36129942	2022	CYCLIN K down-regulation induces androgen receptor gene intronic polyadenylation, variant expression and PARP inhibitor vulnerability in castration-resistant prostate cancer.	6
34289372	2021	Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer.	28
34380030	2021	HIV-1 Nef interacts with the cyclin K/CDK13 complex to antagonize SERINC5 for optimal viral infectivity.	9
34289372	2021	Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer.	28
34380030	2021	HIV-1 Nef interacts with the cyclin K/CDK13 complex to antagonize SERINC5 for optimal viral infectivity.	9
33042275	2020	Cyclin K interacts with β-catenin to induce Cyclin D1 expression and facilitates tumorigenesis and radioresistance in lung cancer.	9
33042275	2020	Cyclin K interacts with β-catenin to induce Cyclin D1 expression and facilitates tumorigenesis and radioresistance in lung cancer.	9
29474905	2018	A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response.	54
29760377	2018	Cyclin K regulates prereplicative complex assembly to promote mammalian cell proliferation.	23
29760377	2018	Cyclin K regulates prereplicative complex assembly to promote mammalian cell proliferation.	23
30122539	2018	De Novo Mutations of CCNK Cause a Syndromic Neurodevelopmental Disorder with Distinctive Facial Dysmorphism.	9
29474905	2018	A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response.	54

Citation

Dessen P

CCNK (cyclin K)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/962/teaching-explorer/js/lib/img/logo-atlas-4.svg