CD68 (CD68 molecule)

2003-11-01  

Identity

HGNC
LOCATION
17p13.1
LOCUSID
ALIAS
GP110,LAMP4,SCARD1
FUSION GENES

Other Information

Locus ID:

NCBI: 968
MIM: 153634
HGNC: 1693
Ensembl: ENSG00000129226

Variants:

dbSNP: 968
ClinVar: 968
TCGA: ENSG00000129226
COSMIC: CD68

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000129226ENST00000250092P34810
ENSG00000129226ENST00000380498P34810
ENSG00000129226ENST00000584180J3KRX0
ENSG00000129226ENST00000584502J3KT24

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
LysosomeKEGGko04142
LysosomeKEGGhsa04142
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
232894762013Expression of M2-polarized macrophages is associated with poor prognosis for advanced epithelial ovarian cancer.63
229480492012Tumor-associated macrophages predict inferior outcomes in classic Hodgkin lymphoma: a correlative study from the E2496 Intergroup trial.57
183165652008Prognostic significance of macrophage infiltration in leiomyosarcomas.53
221630302011Statins promote the regression of atherosclerosis via activation of the CCR7-dependent emigration pathway in macrophages.51
229559182012Gene expression profiling of microdissected Hodgkin Reed-Sternberg cells correlates with treatment outcome in classical Hodgkin lymphoma.41
278697952017CD68/macrosialin: not just a histochemical marker.37
152148252004Granular cell tumor: immunohistochemical assessment of inhibin-alpha, protein gene product 9.5, S100 protein, CD68, and Ki-67 proliferative index with clinical correlation.31
235557762013The clinical significance of the CD163+ and CD68+ macrophages in patients with hepatocellular carcinoma.31
247942512014Infiltration of CD3⁺ and CD68⁺ cells in bladder cancer is subtype specific and affects the outcome of patients with muscle-invasive tumors.31
250300632014Human CD68 promoter GFP transgenic mice allow analysis of monocyte to macrophage differentiation in vivo.30

Citation

Dessen P

CD68 (CD68 molecule)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/987/cd68-(cd68-molecule)