CD7 (CD7 molecule)

2003-11-01  

Identity

HGNC
CD7
LOCATION
17q25.3
LOCUSID
924
ALIAS
GP40,LEU-9,TP41,Tp40

Other Information

Locus ID:

NCBI: 924
MIM: 186820
HGNC: 1695
Ensembl: ENSG00000173762

Variants:

dbSNP: 924
ClinVar: 924
TCGA: ENSG00000173762
COSMIC: CD7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173762ENST00000312648P09564
ENSG00000173762ENST00000312648Q29VG3
ENSG00000173762ENST00000578509J3QS78
ENSG00000173762ENST00000581434J3QS65
ENSG00000173762ENST00000582480J3QRF1
ENSG00000173762ENST00000583376J3QLC7
ENSG00000173762ENST00000584284J3QLM0

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Hematopoietic cell lineageKEGGko04640
Hematopoietic cell lineageKEGGhsa04640

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
123937022003B lymphopoiesis is active throughout human life, but there are developmental age-related changes.32
179598572008Human intrathymic lineage commitment is marked by differential CD7 expression: identification of CD7- lympho-myeloid thymic progenitors.27
247273232014CADM1 expression and stepwise downregulation of CD7 are closely associated with clonal expansion of HTLV-I-infected cells in adult T-cell leukemia/lymphoma.24
163329672006CD7-restricted activation of Fas-mediated apoptosis: a novel therapeutic approach for acute T-cell leukemia.10
172878512007HTLV-I infection of WE17/10 CD4+ cell line leads to progressive alteration of Ca2+ influx that eventually results in loss of CD7 expression and activation of an antiapoptotic pathway involving AKT and BAD which paves the way for malignant transformation.7
199371402009Twist2 regulates CD7 expression and galectin-1-induced apoptosis in mature T-cells.7
241574612014SECTM1 produced by tumor cells attracts human monocytes via CD7-mediated activation of the PI3K pathway.7
168370442007CD7 expression predicts poor disease free survival and post-remission survival in patients with acute myeloid leukemia and normal karyotype.5
183437902008Aberrant expression of CD7 in myeloblasts is highly associated with de novo acute myeloid leukemias with FLT3/ITD mutation.5
189564702009Overexpression of CD7 in classical Hodgkin lymphoma-infiltrating T lymphocytes.5

Citation

Dessen P

CD7 (CD7 molecule)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/989/cd7