CD86 (CD86 molecule)

2004-04-01 Affiliation

Identity

HGNC

CD86

LOCATION

3q13.33

LOCUSID

942

ALIAS

B7-2,B7.2,B70,CD28LG2,LAB72

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 942
MIM: 601020
HGNC: 1705
Ensembl: ENSG00000114013

Variants:

dbSNP: 942
ClinVar: 942
TCGA: ENSG00000114013
COSMIC: CD86

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000114013	ENST00000264468	P42081
ENSG00000114013	ENST00000330540	P42081
ENSG00000114013	ENST00000393627	P42081
ENSG00000114013	ENST00000469710	P42081
ENSG00000114013	ENST00000478741	H7C4F8
ENSG00000114013	ENST00000482356	C9JXS1
ENSG00000114013	ENST00000493101	P42081

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cell adhesion molecules (CAMs)	KEGG	ko04514
Toll-like receptor signaling pathway	KEGG	ko04620
Type I diabetes mellitus	KEGG	ko04940
Autoimmune thyroid disease	KEGG	ko05320
Systemic lupus erythematosus	KEGG	ko05322
Allograft rejection	KEGG	ko05330
Graft-versus-host disease	KEGG	ko05332
Cell adhesion molecules (CAMs)	KEGG	hsa04514
Toll-like receptor signaling pathway	KEGG	hsa04620
Type I diabetes mellitus	KEGG	hsa04940
Autoimmune thyroid disease	KEGG	hsa05320
Systemic lupus erythematosus	KEGG	hsa05322
Allograft rejection	KEGG	hsa05330
Graft-versus-host disease	KEGG	hsa05332
Viral myocarditis	KEGG	hsa05416
Intestinal immune network for IgA production	KEGG	ko04672
Intestinal immune network for IgA production	KEGG	hsa04672
Rheumatoid arthritis	KEGG	ko05323
Rheumatoid arthritis	KEGG	hsa05323
Transcriptional misregulation in cancer	KEGG	ko05202
Transcriptional misregulation in cancer	KEGG	hsa05202
Disease	REACTOME	R-HSA-1643685
Diseases of signal transduction	REACTOME	R-HSA-5663202
PI3K/AKT Signaling in Cancer	REACTOME	R-HSA-2219528
Constitutive Signaling by Aberrant PI3K in Cancer	REACTOME	R-HSA-2219530
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Costimulation by the CD28 family	REACTOME	R-HSA-388841
CD28 co-stimulation	REACTOME	R-HSA-389356
CD28 dependent PI3K/Akt signaling	REACTOME	R-HSA-389357
CD28 dependent Vav1 pathway	REACTOME	R-HSA-389359
CTLA4 inhibitory signaling	REACTOME	R-HSA-389513
Signaling by the B Cell Receptor (BCR)	REACTOME	R-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)	REACTOME	R-HSA-1168372
PIP3 activates AKT signaling	REACTOME	R-HSA-1257604
Negative regulation of the PI3K/AKT network	REACTOME	R-HSA-199418
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
Role of LAT2/NTAL/LAB on calcium mobilization	REACTOME	R-HSA-2730905
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Signal Transduction	REACTOME	R-HSA-162582
Signaling by EGFR	REACTOME	R-HSA-177929
GAB1 signalosome	REACTOME	R-HSA-180292
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
PI3K/AKT activation	REACTOME	R-HSA-198203
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by SCF-KIT	REACTOME	R-HSA-1433557
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	REACTOME	R-HSA-6811558
Interleukin-10 signaling	REACTOME	R-HSA-6783783

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
23470321	2013	Molecular mechanisms of T cell co-stimulation and co-inhibition.	693
21474713	2011	Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4.	428
15034022	2004	Ligation of B7-1/B7-2 by human CD4+ T cells triggers indoleamine 2,3-dioxygenase activity in dendritic cells.	134
17703412	2007	Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.	100
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
11279501	2001	Structural basis for co-stimulation by the human CTLA-4/B7-2 complex.	81
14978077	2004	CD86 and CD80 differentially modulate the suppressive function of human regulatory T cells.	71
11726649	2002	Distinct role of CD80 and CD86 in the regulation of the activation of B cell and B cell lymphoma.	62
12582153	2003	c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity.	59
12486098	2002	Opsonization of apoptotic cells by autologous iC3b facilitates clearance by immature dendritic cells, down-regulates DR and CD86, and up-regulates CC chemokine receptor 7.	57

Citation

Dessen P

CD86 (CD86 molecule)

Atlas Genet Cytogenet Oncol Haematol. 2004-04-01

Online version: http://atlasgeneticsoncology.org/gene/992/cd86-(cd86-molecule)