CD99 (CD99 molecule (Xg blood group))

2003-11-01  

Identity

HGNC
LOCATION
Xp22.33
LOCUSID
ALIAS
HBA71,MIC2,MIC2X,MIC2Y,MSK5X
FUSION GENES

Other Information

Locus ID:

NCBI: 4267
MIM: 450000
HGNC: 7082
Ensembl: ENSG00000002586

Variants:

dbSNP: 4267
ClinVar: 4267
TCGA: ENSG00000002586
COSMIC: CD99

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000002586ENST00000381177A6NGF6
ENSG00000002586ENST00000381180A6NJT9
ENSG00000002586ENST00000381184A8MQT7
ENSG00000002586ENST00000381187P14209
ENSG00000002586ENST00000381192P14209
ENSG00000002586ENST00000482405P14209
ENSG00000002586ENST00000611428P14209
ENSG00000002586ENST00000623253P14209
ENSG00000002586ENST00000624481A0A096LP69

Expression (GTEx)

0
50
100
150
200
250
300
350
400

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Leukocyte transendothelial migrationKEGGko04670
Cell adhesion molecules (CAMs)KEGGhsa04514
Leukocyte transendothelial migrationKEGGhsa04670
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
172023772007CD99 is a key mediator of the transendothelial migration of neutrophils.57
201976222010CD99 inhibits neural differentiation of human Ewing sarcoma cells and thereby contributes to oncogenesis.51
169849172006A splice variant of CD99 increases motility and MMP-9 expression of human breast cancer cells through the AKT-, ERK-, and JNK-dependent AP-1 activation signaling pathways.41
233337542013Poliovirus receptor (CD155) regulates a step in transendothelial migration between PECAM and CD99.31
151848832004Molecular mechanisms of CD99-induced caspase-independent cell death and cell-cell adhesion in Ewing's sarcoma cells: actin and zyxin as key intracellular mediators.29
229865302013MiR-30a-5p connects EWS-FLI1 and CD99, two major therapeutic targets in Ewing tumor.29
174712352007CD99 isoforms dictate opposite functions in tumour malignancy and metastases by activating or repressing c-Src kinase activity.25
164212472006CD99 acts as an oncosuppressor in osteosarcoma.21
281230692017CD99 is a therapeutic target on disease stem cells in myeloid malignancies.20
223925392012CD99 is a novel prognostic stromal marker in non-small cell lung cancer.19

Citation

Dessen P

CD99 (CD99 molecule (Xg blood group))

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/997/cd99-(cd99-molecule-(xg-blood-group))