B-lineage acute lymphoblastic leukemia

Rare in Philadelphia-positive and in Philadelphia-negative B-lineage.

Additional anomalies: Philadelphia-negative ALL: Occurrence in hyperdiploid karyotypes (equal or more than 47 chromosomes) mostly in combination with other numerical gains. Philadelphia-positive ALL: Rare additional change.

Not known.

Philadelphia-negative ALL with high hyperdiploid karyotype (equal or more than 51 chromosomes) shows a good prognosis, gain of chromosome 9 is not typical and prognostic impact of trisomy 9 in this setting unknown. In Philadelphia-positive ALL additional chromosomal anomalies probably enhance the inferior prognosis.

T-lineage acute lymphoblastic leukemia.

Rare, up to 4% in childhood T-ALL.

Additional anomalies: Occurs as sole or as combined anomaly.

Not known.

So far a prognostic impact could not be defined, which also might be due to the low analyzed case numbers.

Occurs in a large spectrum of myeloid and lymphatic malignancies - chronic myeloproliferative disorders (CMPD), acute myeloid leukemias (AML), myelodysplastic syndromes (MDS), acute lymphoblastic leukemias (ALL) of B-lineage and of T-lineage. Strong association to the CMPD and especially to polycythemia vera (PV).