t(1;18)(q25;q23)

1999-09-01 Jean-Loup Huret Affiliation

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

acute myeloid leukemia (AML) and acute lymphocycic leukemia (ALL)

M2 and M6AML, L2-ALL

1 case was a therapy related AML, and the 2 other cases were found in Down syndrome (DS) patients

poorly known: only 3 cases to date; 3 female patients aged 1-13 yrs

yet unknown : cases dead at 1 mth and alive at 2 mths+ (2 DS cases), alive at 12 mths+ (therapy related case)

Pubmed ID	Last Year	Title	Authors
2972356	1988	Cytogenetic findings in leukemic cells of 56 patients with constitutional chromosome abnormalities. A cooperative study. Groupe Français de Cytogénétique Hématologique.
10214363	1999	A second known case of Down syndrome with t(1;18)(q25;q23) in leukemic cells.	Brozek I et al
2713498	1989	Two karyotypically independent leukemic clones with the t(8;21) and 11q23 translocation in acute myeloblastic leukemia at relapse.	Hayashi Y et al

Jean-Loup Huret

t(1;18)(q25;q23)

Atlas Genet Cytogenet Oncol Haematol. 1999-09-01