1.Department of Pathology and Laboratory Medicine, Beaumont Health and Oakland University William Beaumont School of Medicine, Royal Oak, MI 48073; mmicale@beaumont.edu
T-cell acute lymphoblastic leukemia is identified in 10-25% of all newly diagnosed acute lymphoblastic leukemias in children. The disease results from cytogenetic and molecular abnormalities which disrupt key oncogenic, tumor suppressor, and developmental pathways which control normal thymocyte development. Disruption of key pathways alter normal control of cell growth and proliferation, along with survival and differentiation. This paper provides an update on the cytogenetic and molecular basis of pediatric T-cell acute lymphoblastic leukemia.
Mark A. Micale
Pediatric T-Cell Acute Lymphoblastic Leukemia
Atlas Genet Cytogenet Oncol Haematol. 2017-10-01
Online version: http://atlasgeneticsoncology.org/haematological/1292/pediatric-t-cell-acute-lymphoblastic-leukemia