t(2;8)(p15;q24) BCL11A/MYC

2013-09-01   Jean-Loup Huret 

1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Clinics and Pathology

Disease

Diffuse large B-cell lymphoma (DLBCL)

Epidemiology

There was one female patient, and a male patient aged 81 years (Aamot et al., 2007; Bertrand et al., 2007).

Prognosis

One patient died before treatment (Bertrand et al., 2007).

Genes Involved and Proteins

Note
In the case described by Bertrand et al., 2007, breakpoints occurred close to MYC and BCL11A.
Gene name
BCL11A (B-cell lymphoma/leukemia 11A)
Location
2p16.1
Protein description
BCL11A is a Krüppel zinc-finger transcription factor, which has been shown to be essential for pre-B-cell development, thymocyte maturation, and globin switching, expressed in haematopoietic and neural tissues. BCL11A controls FLT3 and IL7R expression in early hematopoietic progenitors (Wu et al., 2013).
Gene name
MYC v-myc myelocytomatosis viral oncogene homolog (avian)
Location
8q24.21
Protein description
DNA binding protein. Binds DNA as a heterodimer with MAX. Involved in various cellular processes including cell growth, proliferation, cell adhesion, apoptosis, angiogenesis, and stem cell behaviour modulation.

Bibliography

Pubmed IDLast YearTitleAuthors
172355512007Non-Hodgkin lymphoma with t(14;18): clonal evolution patterns and cytogenetic-pathologic-clinical correlations.Aamot HV et al
172302272007Mapping of MYC breakpoints in 8q24 rearrangements involving non-immunoglobulin partners in B-cell lymphomas.Bertrand P et al
237413952013Bcl11a controls Flt3 expression in early hematopoietic progenitors and is required for pDC development in vivo.Wu X et al

Citation

Jean-Loup Huret

t(2;8)(p15;q24) BCL11A/MYC

Atlas Genet Cytogenet Oncol Haematol. 2013-09-01

Online version: http://atlasgeneticsoncology.org/haematological/2138/t(2;8)(p15;q24)